Literature DB >> 11166566

The evolution of ribonucleotide reduction revisited.

J Stubbe1, J Ge, C S Yee.   

Abstract

Ribonucleotide reductases (RNRs) catalyze the conversion of both purine and pyrimidine nucleotides to deoxynucleotides in all organisms and provide all the monomeric precursors essential for both DNA replication and repair. RNRs have been divided into three classes on the basis of their unique metallo-cofactors. The exquisitely controlled free radical chemistry used by all RNRs, and the commonality of the structures of the subunits where the nucleotide reduction process occurs, together provide compelling evidence for the importance of chemistry in the divergent evolution of RNRs from a common progenitor.

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Year:  2001        PMID： 11166566     DOI： 10.1016/s0968-0004(00)01764-3

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  23 in total

1.  Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.

Authors:  Damien Leduc; Sébastien Graziani; Gerard Lipowski; Christophe Marchand; Pierre Le Maréchal; Ursula Liebl; Hannu Myllykallio
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-27       Impact factor: 11.205

2.  Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase.

Authors:  Allison D Ortigosa; Daniela Hristova; Deborah L Perlstein; Zhen Zhang; Mingxia Huang; JoAnne Stubbe
Journal:  Biochemistry       Date:  2006-10-10       Impact factor: 3.162

3.  Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.

Authors:  Zhen Zhang; Xiuxiang An; Kui Yang; Deborah L Perlstein; Leslie Hicks; Neil Kelleher; JoAnne Stubbe; Mingxia Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

4.  Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasm.

Authors:  Xiuxiang An; Zhen Zhang; Kui Yang; Mingxia Huang
Journal:  Genetics       Date:  2006-02-19       Impact factor: 4.562

5.  Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1.

Authors:  Zhen Zhang; Kui Yang; Chin-Chuan Chen; Jason Feser; Mingxia Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-02       Impact factor: 11.205

Review 6.  Darwin's warm little pond revisited: from molecules to the origin of life.

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Journal:  Naturwissenschaften       Date:  2009-09-17

7.  Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase.

Authors:  Md Faiz Ahmad; Qun Wan; Shalini Jha; Edward Motea; Anthony Berdis; Chris Dealwis
Journal:  Mol Cancer Ther       Date:  2012-08-28       Impact factor: 6.261

Review 8.  Glycyl radical activating enzymes: structure, mechanism, and substrate interactions.

Authors:  Krista A Shisler; Joan B Broderick
Journal:  Arch Biochem Biophys       Date:  2014-01-31       Impact factor: 4.013

9.  Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.

Authors:  Ruojin Yao; Zhen Zhang; Xiuxiang An; Brigid Bucci; Deborah L Perlstein; JoAnne Stubbe; Mingxia Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-05       Impact factor: 11.205

10.  Anaerobic growth of Bacillus mojavensis and Bacillus subtilis requires deoxyribonucleosides or DNA.

Authors:  Martha J Folmsbee; Michael J McInerney; David P Nagle
Journal:  Appl Environ Microbiol       Date:  2004-09       Impact factor: 4.792
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