Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer.

Literature DB >> 11161397

Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer.

W K Leung¹, K F To, Y P Ng, T L Lee, J Y Lau, F K Chan, E K Ng, S C Chung, J J Sung.

Abstract

Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 2001 PMID： 11161397 PMCID： PMC2363738 DOI： 10.1054/bjoc.2000.1607

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

23 in total

1. Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level.

Authors: L C Hsi; J Angerman-Stewart; T E Eling
Journal: Carcinogenesis Date: 1999-11 Impact factor: 4.944

2. Frequent allelic losses and mutations of the p53 gene in human ovarian cancer.

Authors: A Okamoto; Y Sameshima; S Yokoyama; Y Terashima; T Sugimura; M Terada; J Yokota
Journal: Cancer Res Date: 1991-10-01 Impact factor: 12.701

3. DNA damage and mutation in human cells exposed to nitric oxide in vitro.

Authors: T Nguyen; D Brunson; C L Crespi; B W Penman; J S Wishnok; S R Tannenbaum
Journal: Proc Natl Acad Sci U S A Date: 1992-04-01 Impact factor: 11.205

4. Base transitions are the most frequent genetic changes at P53 in gastric cancer.

Authors: B Renault; M van den Broek; R Fodde; J Wijnen; N S Pellegata; D Amadori; P M Khan; G N Ranzani
Journal: Cancer Res Date: 1993-06-01 Impact factor: 12.701

5. Mutational hotspot in the p53 gene in human hepatocellular carcinomas.

Authors: I C Hsu; R A Metcalf; T Sun; J A Welsh; N J Wang; C C Harris
Journal: Nature Date: 1991-04-04 Impact factor: 49.962

6. p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer.

Authors: S Uchino; M Noguchi; A Ochiai; T Saito; M Kobayashi; S Hirohashi
Journal: Int J Cancer Date: 1993-07-09 Impact factor: 7.396

7. Missense mutations and a deletion of the p53 gene in human gastric cancer.

Authors: T Matozaki; C Sakamoto; K Matsuda; T Suzuki; Y Konda; O Nakano; K Wada; T Uchida; H Nishisaki; M Nagao
Journal: Biochem Biophys Res Commun Date: 1992-01-15 Impact factor: 3.575

8. Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

Authors: D H Mack; J Vartikar; J M Pipas; L A Laimins
Journal: Nature Date: 1993-05-20 Impact factor: 49.962

9. Wild-type p53 binds to the TATA-binding protein and represses transcription.

Authors: E Seto; A Usheva; G P Zambetti; J Momand; N Horikoshi; R Weinmann; A J Levine; T Shenk
Journal: Proc Natl Acad Sci U S A Date: 1992-12-15 Impact factor: 11.205

10. p53 gene mutations in gastric and esophageal cancers.

Authors: F Imazeki; M Omata; H Nose; M Ohto; K Isono
Journal: Gastroenterology Date: 1992-09 Impact factor: 22.682

21 in total

Review 1. Cyclooxygenase-2 expression is associated with poor overall survival of patients with gastric cancer: a meta-analysis.

Authors: Jian Song; Hong Su; Yang-Yang Zhou; Liang-Liang Guo
Journal: Dig Dis Sci Date: 2013-11-01 Impact factor: 3.199

2. MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer.

Authors: J Mrena; J-P Wiksten; S Nordling; A Kokkola; A Ristimäki; C Haglund
Journal: J Clin Pathol Date: 2006-06 Impact factor: 3.411

3. NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression.

Authors: Panagiotis A Konstantinopoulos; Gerasimos P Vandoros; Georgia Sotiropoulou-Bonikou; Athina Kominea; Athanasios G Papavassiliou
Journal: Int J Colorectal Dis Date: 2006-02-25 Impact factor: 2.571

4. Quantitative measurement of m-RNA levels to assess expression of cyclooxygenase-II, inducible nitric oxide synthase and 12-lipoxygenase genes in middle ear cholesteatoma.

Authors: Tolgahan Çatlı; Yıldırım Bayazıt; Akın Yılmaz; Adnan Menevşe; Ozan Gökdoğan; Nebil Göksu; Suat Özbilen
Journal: Eur Arch Otorhinolaryngol Date: 2013-07-06 Impact factor: 2.503

5. Celecoxib inhibits proliferation and induces apoptosis via cyclooxygenase-2 pathway in human pancreatic carcinoma cells.

Authors: Gaosong Wu; Jilin Yi; Fang Di; Shengquan Zou; Xingrui Li
Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2005

6. COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer.

Authors: Johanna Mrena; Jan-Patrik Wiksten; Arto Kokkola; Stig Nordling; Ari Ristimäki; Caj Haglund
Journal: Tumour Biol Date: 2009-12-18