Literature DB >> 1465435

Wild-type p53 binds to the TATA-binding protein and represses transcription.

E Seto1, A Usheva, G P Zambetti, J Momand, N Horikoshi, R Weinmann, A J Levine, T Shenk.   

Abstract

p53 activates transcription of genes with a p53 response element, and it can repress genes lacking the element. Here we demonstrate that wild-type but not mutant p53 inhibits transcription in a HeLa nuclear extract from minimal promoters. Wild-type but not mutant p53 binds to human TATA-binding protein (TBP). p53 does not bind to yeast TBP, and it cannot inhibit transcription in a HeLa extract where yeast TBP substitutes for human TBP. These results suggest a model in which p53 binds to TBP and interferes with transcriptional initiation.

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Year:  1992        PMID： 1465435      PMCID： PMC50691          DOI： 10.1073/pnas.89.24.12028

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

1.  Rearrangement of the p53 gene in human osteogenic sarcomas.

Authors:  H Masuda; C Miller; H P Koeffler; H Battifora; M J Cline
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

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Journal:  Science       Date:  1990-08-31       Impact factor: 47.728

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Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

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Authors:  I Sadowski; J Ma; S Triezenberg; M Ptashne
Journal:  Nature       Date:  1988-10-06       Impact factor: 49.962

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Authors:  S T Smale; D Baltimore
Journal:  Cell       Date:  1989-04-07       Impact factor: 41.582

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Authors:  G Gill; M Ptashne
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

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Authors:  G J Matlashewski; S Tuck; D Pim; P Lamb; J Schneider; L V Crawford
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

8.  Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

Authors:  C A Finlay; P W Hinds; T H Tan; D Eliyahu; M Oren; A J Levine
Journal:  Mol Cell Biol       Date:  1988-02       Impact factor: 4.272

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Authors:  A H Rosenberg; B N Lade; D S Chui; S W Lin; J J Dunn; F W Studier
Journal:  Gene       Date:  1987       Impact factor: 3.688

10.  Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

Authors:  P W Hinds; C A Finlay; R S Quartin; S J Baker; E R Fearon; B Vogelstein; A J Levine
Journal:  Cell Growth Differ       Date:  1990-12
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  153 in total

1.  Analysis of p53-regulated gene expression patterns using oligonucleotide arrays.

Authors:  R Zhao; K Gish; M Murphy; Y Yin; D Notterman; W H Hoffman; E Tom; D H Mack; A J Levine
Journal:  Genes Dev       Date:  2000-04-15       Impact factor: 11.361

Review 2.  Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress.

Authors:  M Ljungman
Journal:  Neoplasia       Date:  2000 May-Jun       Impact factor: 5.715

3.  Relationship of p53 mutations to epidermal cell proliferation and apoptosis in human UV-induced skin carcinogenesis.

Authors:  J G Einspahr; D S Alberts; J A Warneke; P Bozzo; J Basye; T M Grogan; M A Nelson; G T Bowden
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

4.  Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.

Authors:  Penny G Ard; Chandrima Chatterjee; Sudeesha Kunjibettu; Leon R Adside; Lisa E Gralinski; Steven B McMahon
Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

5.  Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis.

Authors:  Nelly Godefroy; Sylvina Bouleau; Gaëtan Gruel; Flore Renaud; Vincent Rincheval; Bernard Mignotte; Diana Tronik-Le Roux; Jean-Luc Vayssière
Journal:  Nucleic Acids Res       Date:  2004-08-23       Impact factor: 16.971

6.  The RP-p53-Mdm2 pathway: a new link to genetic integrity?

Authors:  Rebeca A Frum; Yanping Zhang
Journal:  Cell Cycle       Date:  2010-11-15       Impact factor: 4.534

7.  Mouse p53 represses the rat brain creatine kinase gene but activates the rat muscle creatine kinase gene.

Authors:  J Zhao; F I Schmieg; D T Simmons; G R Molloy
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

8.  The ability to associate with activation domains in vitro is not required for the TATA box-binding protein to support activated transcription in vivo.

Authors:  W P Tansey; W Herr
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

9.  The cellular TATA binding protein is required for rep-dependent replication of a minimal adeno-associated virus type 2 p5 element.

Authors:  Achille François; Mickaël Guilbaud; Rafi Awedikian; Gilliane Chadeuf; Philippe Moullier; Anna Salvetti
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

10.  Transcription stimulation of the adenovirus type 12 E1a gene in vitro by the 266-amino-acid E1A protein.

Authors:  H Kawamura; N Wada; Y Makino; T A Tamura; S Koikeda; K Shiroki; Y Masamune; Y Nakanishi
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103
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