Literature DB >> 11160153

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development.

U I Chung1, E Schipani, A P McMahon, H M Kronenberg.   

Abstract

Vertebrate skeletogenesis requires a well-coordinated transition from chondrogenesis to osteogenesis. Hypertrophic chondrocytes in the growth plate play a pivotal role in this transition. Parathyroid hormone-related peptide (PTHrP), synthesized in the periarticular growth plate, regulates the site at which hypertrophy occurs. By comparing PTH/PTHrP receptor(-/-)/wild-type (PPR(-/-)/wild-type) chimeric mice with IHH(-/-);PPR(-/-)/wild-type chimeric and IHH(-/-)/wild-type chimeric mice, we provide in vivo evidence that Indian hedgehog (IHH), synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development.

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Year:  2001        PMID： 11160153      PMCID： PMC199199          DOI： 10.1172/JCI11706

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  30 in total

1.  The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.

Authors:  D M Stone; M Hynes; M Armanini; T A Swanson; Q Gu; R L Johnson; M P Scott; D Pennica; A Goddard; H Phillips; M Noll; J E Hooper; F de Sauvage; A Rosenthal
Journal:  Nature       Date:  1996-11-14       Impact factor: 49.962

2.  Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells.

Authors:  B P Zambrowicz; A Imamoto; S Fiering; L A Herzenberg; W G Kerr; P Soriano
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

3.  Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.

Authors:  A Vortkamp; K Lee; B Lanske; G V Segre; H M Kronenberg; C J Tabin
Journal:  Science       Date:  1996-08-02       Impact factor: 47.728

4.  PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.

Authors:  B Lanske; A C Karaplis; K Lee; A Luz; A Vortkamp; A Pirro; M Karperien; L H Defize; C Ho; R C Mulligan; A B Abou-Samra; H Jüppner; G V Segre; H M Kronenberg
Journal:  Science       Date:  1996-08-02       Impact factor: 47.728

5.  Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation.

Authors:  N Kinto; M Iwamoto; M Enomoto-Iwamoto; S Noji; H Ohuchi; H Yoshioka; H Kataoka; Y Wada; G Yuhao; H E Takahashi; S Yoshiki; A Yamaguchi
Journal:  FEBS Lett       Date:  1997-03-10       Impact factor: 4.124

6.  A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.

Authors:  E Schipani; K Kruse; H Jüppner
Journal:  Science       Date:  1995-04-07       Impact factor: 47.728

7.  Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

Authors:  E C Weir; W M Philbrick; M Amling; L A Neff; R Baron; A E Broadus
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

8.  Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

Authors:  L V Goodrich; R L Johnson; L Milenkovic; J A McMahon; M P Scott
Journal:  Genes Dev       Date:  1996-02-01       Impact factor: 11.361

9.  Biochemical evidence that patched is the Hedgehog receptor.

Authors:  V Marigo; R A Davey; Y Zuo; J M Cunningham; C J Tabin
Journal:  Nature       Date:  1996-11-14       Impact factor: 49.962

10.  Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice.

Authors:  J Rossert; H Eberspaecher; B de Crombrugghe
Journal:  J Cell Biol       Date:  1995-06       Impact factor: 10.539
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  126 in total

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4.  Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.

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Review 5.  Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development.

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Review 6.  Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation.

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Journal:  J Bone Miner Metab       Date:  2005       Impact factor: 2.626

7.  Physiological role of bone morphogenetic proteins in osteogenesis.

Authors:  Fumitaka Kugimiya; Shinsuke Ohba; Kozo Nakamura; Hiroshi Kawaguchi; Ung-Il Chung
Journal:  J Bone Miner Metab       Date:  2006       Impact factor: 2.626

8.  PLXNA2 identified as a candidate gene by genome-wide association analysis for mandibular prognathism in human chondrocytes.

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9.  Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.

Authors:  Weiguang Wang; Na Lian; Lingzhen Li; Heather E Moss; Weixi Wang; Daniel S Perrien; Florent Elefteriou; Xiangli Yang
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10.  Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation.

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