Literature DB >> 11148522

Abundant human beta-defensin-1 expression in milk and mammary gland epithelium.

H P Jia1, T Starner, M Ackermann, P Kirby, B F Tack, P B McCray.   

Abstract

Human beta-defensin-1 (HBD-1) was detected in breast milk in concentrations of approximately 1 to 10 microg/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The peptide demonstrated antimicrobial activity against Escherichia coli. HBD-1 may augment neonatal host defenses through antimicrobial effects or prime the adaptive immune system at mucosal surfaces.

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Year:  2001        PMID： 11148522     DOI： 10.1067/mpd.2001.109375

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  17 in total

Review 1.  Mammary gland immunity and mastitis susceptibility.

Authors:  Lorraine M Sordillo; Katie L Streicher
Journal:  J Mammary Gland Biol Neoplasia       Date:  2002-04       Impact factor: 2.673

Review 2.  The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota.

Authors:  Vanessa Liévin-Le Moal; Alain L Servin
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

3.  Defensins and other antimicrobial peptides at the ocular surface.

Authors:  Alison M McDermott
Journal:  Ocul Surf       Date:  2004-10       Impact factor: 5.033

Review 4.  Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: past, present, and future.

Authors:  Caitlin A Cooper; Elizabeth A Maga; James D Murray
Journal:  Transgenic Res       Date:  2015-06-10       Impact factor: 2.788

5.  Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis.

Authors:  Kara Swanson; Stas Gorodetsky; Laura Good; Stephen Davis; David Musgrave; Kerst Stelwagen; Vicki Farr; Adrian Molenaar
Journal:  Infect Immun       Date:  2004-12       Impact factor: 3.441

Review 6.  Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding--an extrauterine link between mother and child.

Authors:  Samuli Rautava; W Allan Walker
Journal:  Breastfeed Med       Date:  2009-03       Impact factor: 1.817

7.  Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms.

Authors:  Aprille Seidel; Ying Ye; Lesley R de Armas; Maira Soto; William Yarosh; Renee A Marcsisin; Dat Tran; Michael E Selsted; David Camerini
Journal:  PLoS One       Date:  2010-03-17       Impact factor: 3.240

8.  Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle.

Authors:  T Goldammer; H Zerbe; A Molenaar; H-J Schuberth; R M Brunner; S R Kata; H-M Seyfert
Journal:  Clin Diagn Lab Immunol       Date:  2004-01

Review 9.  The role of antimicrobial peptides at the ocular surface.

Authors:  Alison M McDermott
Journal:  Ophthalmic Res       Date:  2008-12-20       Impact factor: 2.892

10.  Maternal milk contains antimicrobial factors that protect young rabbits from enteropathogenic Escherichia coli infection.

Authors:  Mélanie Gallois; Thierry Gidenne; Christian Tasca; Cécile Caubet; Cécile Coudert; Alain Milon; Séverine Boullier
Journal:  Clin Vaccine Immunol       Date:  2007-03-07
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