Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis.

Literature DB >> 15557657

Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis.

Kara Swanson¹, Stas Gorodetsky, Laura Good, Stephen Davis, David Musgrave, Kerst Stelwagen, Vicki Farr, Adrian Molenaar.

Abstract

The expression of a beta-defensin, the lingual antimicrobial peptide (LAP), in response to mastitis was investigated by real-time PCR of RNA from mastitic and control udder quarters. There was a positive relationship between somatic cell count in milk and LAP expression. In situ hybridization showed that LAP mRNA was expressed in epithelial cells of mastitic tissue. These results suggest that LAP plays a role in the innate immune response to mastitis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15557657 PMCID： PMC529112 DOI： 10.1128/IAI.72.12.7311-7314.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. Expression of alpha-lactalbumin, alpha-S1-casein, and lactoferrin genes is heterogeneous in sheep and cattle mammary tissue.

Authors: A J Molenaar; S R Davis; R J Wilkins
Journal: J Histochem Cytochem Date: 1992-05 Impact factor: 2.479

2. Effect of milking frequency on milk somatic cell count characteristics and mammary secretory cell damage in cows.

Authors: K Stelwagen; S J Lacy-Hulbert
Journal: Am J Vet Res Date: 1996-06 Impact factor: 1.156

3. Conversion of chronic staphylococcal mastitis to acute gangrenous mastitis after neutropenia in blood and bone marrow produced by an equine anti-bovine leukocyte serum.

Authors: O W Schalm; J Lasmanis; N C Jain
Journal: Am J Vet Res Date: 1976-08 Impact factor: 1.156

4. Elevation of lactoferrin gene expression in developing, ductal, resting, and regressing parenchymal epithelium of the ruminant mammary gland.

Authors: A J Molenaar; Y M Kuys; S R Davis; R J Wilkins; P E Mead; J W Tweedie
Journal: J Dairy Sci Date: 1996-07 Impact factor: 4.034

5. Cell counts and composition of bovine milk.

Authors: J O King
Journal: Vet Rec Date: 1978-10-28 Impact factor: 2.695

6. Bactericidal potency and mechanistic specificity of neutrophil defensins against bovine mastitis pathogens.

Authors: J S Cullor; S Wood; W Smith; L Panico; M E Selsted
Journal: Vet Microbiol Date: 1991-09 Impact factor: 3.293

Review 7. Defensins: a family of antimicrobial and cytotoxic peptides.

Authors: B L Kagan; T Ganz; R I Lehrer
Journal: Toxicology Date: 1994-02-28 Impact factor: 4.221

8. The cell count of milk in relation to milk yield.

Authors: A Meijering; F H Jaartsveld; M W Verstegen; M J Tielen
Journal: J Dairy Res Date: 1978-02 Impact factor: 1.904

9. Epithelial antibiotics induced at sites of inflammation.

Authors: B S Schonwetter; E D Stolzenberg; M A Zasloff
Journal: Science Date: 1995-03-17 Impact factor: 47.728

10. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha.

Authors: J P Russell; G Diamond; A P Tarver; T F Scanlin; C L Bevins
Journal: Infect Immun Date: 1996-05 Impact factor: 3.441

31 in total

1. A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media.

Authors: Glen McGillivary; William C Ray; Charles L Bevins; Robert S Munson; Lauren O Bakaletz
Journal: Mol Immunol Date: 2006-11-20 Impact factor: 4.407

Review 2. Immune components of colostrum and milk--a historical perspective.

Authors: Thomas T Wheeler; Alison J Hodgkinson; Colin G Prosser; Stephen R Davis
Journal: J Mammary Gland Biol Neoplasia Date: 2007-11-09 Impact factor: 2.673

3. Molecular analysis and recombinant expression of bovine neutrophil β-defensin 12 and its antimicrobial activity.

Authors: Jianming Wu; Changfa Wang; Hongbin He; Guixue Hu; Hongjun Yang; Yundong Gao; Jifeng Zhong
Journal: Mol Biol Rep Date: 2010-03-28 Impact factor: 2.316

4. The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells.

Authors: Jun Yang; Yongming Sang; Kieran G Meade; Chris Ross
Journal: Immunogenetics Date: 2011-06-15 Impact factor: 2.846

10. Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism.

Authors: Kasey M Moyes; James K Drackley; Dawn E Morin; Massimo Bionaz; Sandra L Rodriguez-Zas; Robin E Everts; Harris A Lewin; Juan J Loor
Journal: BMC Genomics Date: 2009-11-19 Impact factor: 3.969