BACKGROUND: For invasive treatment of atrial fibrillation, linear lesions induced with multipolar ablation catheters (MAC) are needed to prevent recurrence. The aim of the study was to compare the efficacy of pulsed versus continuous radiofrequency (RF)-energy delivery using MAC. METHODS: In vitro tests were performed using endomyocardial preparations of fresh pig hearts in a 10-liter-bath of physiologic saline solution (37 degrees C) at constant flow conditions (1.5 l/min). The MAC were placed with a constant pressure of 20 ponds onto the endocardium. The energy (generator: Osypka HAT 200 S) was delivered either pulsed (4 electrodes simultaneously, 5ms duty-cycle) or continuously (each electrode separately). In vivo experiments were performed in 6 anesthetized pigs using fluoroscopic positioning of MAC at 40 different intracardial positions and with similar conditions as in vitro experiments. Lesion volume (LV) was calculated after measuring lesion diameter with a microcaliper. The homogeneity of the lesions (LH) was classified from 1-4; with 1 as highest homogeneity. RESULTS: Pulsed energy delivery produced more homogeneous linear lesions in significantly less time. There was no difference in electrode temperature values (50.2 +/- 0.8 and 51.3 +/- 1.4 degrees C) in vitro and in vivo. In the in vivo experiments, lesion depth and calculated lesion volume were less in both modes of energy delivery but pulsed energy delivery was superior regarding lesion depth and homogeneity. CONCLUSION: With pulsed energy delivery it is possible to create linear lesions of significantly greater homogeneity. Moreover, larger lesions are induced in less time by pulsed energy delivery in vitro and in vivo.
BACKGROUND: For invasive treatment of atrial fibrillation, linear lesions induced with multipolar ablation catheters (MAC) are needed to prevent recurrence. The aim of the study was to compare the efficacy of pulsed versus continuous radiofrequency (RF)-energy delivery using MAC. METHODS: In vitro tests were performed using endomyocardial preparations of fresh pig hearts in a 10-liter-bath of physiologic saline solution (37 degrees C) at constant flow conditions (1.5 l/min). The MAC were placed with a constant pressure of 20 ponds onto the endocardium. The energy (generator: Osypka HAT 200 S) was delivered either pulsed (4 electrodes simultaneously, 5ms duty-cycle) or continuously (each electrode separately). In vivo experiments were performed in 6 anesthetized pigs using fluoroscopic positioning of MAC at 40 different intracardial positions and with similar conditions as in vitro experiments. Lesion volume (LV) was calculated after measuring lesion diameter with a microcaliper. The homogeneity of the lesions (LH) was classified from 1-4; with 1 as highest homogeneity. RESULTS: Pulsed energy delivery produced more homogeneous linear lesions in significantly less time. There was no difference in electrode temperature values (50.2 +/- 0.8 and 51.3 +/- 1.4 degrees C) in vitro and in vivo. In the in vivo experiments, lesion depth and calculated lesion volume were less in both modes of energy delivery but pulsed energy delivery was superior regarding lesion depth and homogeneity. CONCLUSION: With pulsed energy delivery it is possible to create linear lesions of significantly greater homogeneity. Moreover, larger lesions are induced in less time by pulsed energy delivery in vitro and in vivo.
Authors: H Calkins; J Hall; K Ellenbogen; G Walcott; M Sherman; W Bowe; J Simpson; T Castellano; G N Kay Journal: Am J Cardiol Date: 1999-03-11 Impact factor: 2.778
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Authors: C Pappone; G Oreto; F Lamberti; G Vicedomini; M L Loricchio; S Shpun; M Rillo; M P Calabrò; A Conversano; S A Ben-Haim; R Cappato; S Chierchia Journal: Circulation Date: 1999-09-14 Impact factor: 29.690
Authors: G Hindricks; W Haverkamp; H Gülker; U Rissel; T Budde; K D Richter; M Borggrefe; G Breithardt Journal: Eur Heart J Date: 1989-11 Impact factor: 29.983
Authors: J L Cox; J P Boineau; R B Schuessler; T B Ferguson; M E Cain; B D Lindsay; P B Corr; K M Kater; D G Lappas Journal: JAMA Date: 1991-10-09 Impact factor: 56.272
Authors: Ali Erdogan; Eiko Walleck; Sebastian Rueckleben; Thomas Neumann; Harald H Tillmanns; Bernd Waldecker; Hans Hoelschermann; Martin Heidt Journal: J Interv Card Electrophysiol Date: 2006-12-13 Impact factor: 1.900