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Literature DB >> 11141201

Perspectives: does amiodarone increase non-sudden deaths? If so, why?

Abstract

Despite the antiarrhythmic efficacy of amiodarone, a definitive correlation between amiodarone treatment and increased non-arrhythmic mortality in patients with heart failure and depressed ventricular function has been reported. Results from research in the field of cardiac resynchronization therapy in heart failure may provide some explanations to this observation. We discussed the hypothetical link between amiodarone and non-arrhythmic mortality, which might have a cause--effect relationship, based on cardiac electromechanical disarrangement provoked by electrophysiological properties of amiodarone.

Entities: Chemical Disease Species

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Year: 2000 PMID： 11141201 DOI： 10.1023/a:1026505329169

Source DB: PubMed Journal: J Interv Card Electrophysiol ISSN： 1383-875X Impact factor: 1.900

38 in total

1. Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators.

Authors: B M Massie; S G Fisher; M Radford; P C Deedwania; B N Singh; R D Fletcher; S N Singh
Journal: Circulation Date: 1996-06-15 Impact factor: 29.690

2. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation.

Authors: K D Aaronson; J S Schwartz; T M Chen; K L Wong; J E Goin; D M Mancini
Journal: Circulation Date: 1997-06-17 Impact factor: 29.690

3. Survival after implantation of the cardioverter defibrillator.

Authors: D Newman; M J Sauve; J Herre; J J Langberg; M A Lee; C Titus; J Franklin; M M Scheinman; J C Griffin
Journal: Am J Cardiol Date: 1992-04-01 Impact factor: 2.778

4. Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study.

Authors: R Sheldon; S Connolly; A Krahn; R Roberts; M Gent; M Gardner
Journal: Circulation Date: 2000-04-11 Impact factor: 29.690

5. Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Investigators.

Authors: J A Cairns; S J Connolly; R Roberts; M Gent
Journal: Lancet Date: 1997-03-08 Impact factor: 79.321

6. Influence of the implantable cardioverter/defibrillator on sudden death and total mortality in patients evaluated for cardiac transplantation.

Authors: M O Sweeney; J N Ruskin; H Garan; B A McGovern; M L Guy; D F Torchiana; G J Vlahakes; J B Newell; M J Semigran; G W Dec
Journal: Circulation Date: 1995-12-01 Impact factor: 29.690

7. Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA)

Authors: H C Doval; D R Nul; H O Grancelli; S V Perrone; G R Bortman; R Curiel
Journal: Lancet Date: 1994-08-20 Impact factor: 79.321

Perspectives: does amiodarone increase non-sudden deaths? If so, why?

1. Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators.

2. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation.

3. Survival after implantation of the cardioverter defibrillator.

4. Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study.

5. Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Investigators.

6. Influence of the implantable cardioverter/defibrillator on sudden death and total mortality in patients evaluated for cardiac transplantation.

7. Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA)

8. Chronic effects of amiodarone in patients with refractory ventricular tachycardia.

9. Mechanisms of depressed conduction from long-term amiodarone therapy in canine myocardium.

10. High dose oral amiodarone loading exerts important hemodynamic actions in patients with congestive heart failure.

1. Thyroid hormone, amiodarone therapy, and prognosis in left ventricular systolic dysfunction.

2. Benefits and risks of long-term amiodarone therapy for persistent atrial fibrillation: a meta-analysis.