| Literature DB >> 11140728 |
S X Cai1, H Z Zhang, J Guastella, J Drewe, W Yang, E Weber.
Abstract
N-Octyloxycarbonyl-R110 (1), with enhanced cell penetration and retention properties, was prepared from rhodamine 110. The tetrapeptide substrate N-Ac-DEVD-N'-octyloxycarbonyl-R110 (3) was prepared and shown to be efficiently cleaved by human recombinant caspase-3 and by apoptotic HL-60 cells. This substrate should prove useful in cell-based assays for apoptosis inducers and inhibitors.Entities:
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Year: 2001 PMID： 11140728 DOI： 10.1016/s0960-894x(00)00590-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823