Literature DB >> 11134317

A single amino acid substitution in the ICP27 protein of herpes simplex virus type 1 is responsible for its resistance to leptomycin B.

T Murata1, F Goshima, T Koshizuka, H Takakuwa, Y Nishiyama.   

Abstract

Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequences revealed that a single amino acid substitution within the ICP27 gene is responsible for conferring this resistance.

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Year:  2001        PMID： 11134317      PMCID： PMC114000          DOI： 10.1128/JVI.75.2.1039-1043.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  39 in total

1.  The open reading frame 57 gene product of herpesvirus saimiri shuttles between the nucleus and cytoplasm and is involved in viral RNA nuclear export.

Authors:  D J Goodwin; K T Hall; A J Stevenson; A F Markham; A Whitehouse
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

2.  CRM1 is an export receptor for leucine-rich nuclear export signals.

Authors:  M Fornerod; M Ohno; M Yoshida; I W Mattaj
Journal:  Cell       Date:  1997-09-19       Impact factor: 41.582

3.  The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation.

Authors:  W E Mears; S A Rice
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

4.  Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27.

Authors:  C A Panagiotidis; E K Lium; S J Silverstein
Journal:  J Virol       Date:  1997-02       Impact factor: 5.103

5.  Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.

Authors:  S A Richards; K L Carey; I G Macara
Journal:  Science       Date:  1997-06-20       Impact factor: 47.728

6.  Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.

Authors:  B Wolff; J J Sanglier; Y Wang
Journal:  Chem Biol       Date:  1997-02

7.  Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.

Authors:  T M Soliman; R M Sandri-Goldin; S J Silverstein
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

8.  Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect.

Authors:  W R Hardy; R M Sandri-Goldin
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  Herpes simplex virus type 1 protein IE63 affects the nuclear export of virus intron-containing transcripts.

Authors:  A Phelan; J Dunlop; J B Clements
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

10.  Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.

Authors:  N Kudo; S Khochbin; K Nishi; K Kitano; M Yanagida; M Yoshida; S Horinouchi
Journal:  J Biol Chem       Date:  1997-11-21       Impact factor: 5.157
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  11 in total

1.  CRM1-dependent function of a cis-acting RNA export element.

Authors:  Ileana Popa; Matthew E Harris; John E Donello; Thomas J Hope
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

2.  ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells.

Authors:  Angela Pearson; David M Knipe; Donald M Coen
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

3.  Viral regulation of mRNA export.

Authors:  Rozanne M Sandri-Goldin
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

4.  Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 gene.

Authors:  Jennifer A Corcoran; Wei-Li Hsu; James R Smiley
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

5.  Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.

Authors:  Ron Geller; Marco Vignuzzi; Raul Andino; Judith Frydman
Journal:  Genes Dev       Date:  2007-01-15       Impact factor: 11.361

6.  Mapping of functional regions in the amino-terminal portion of the herpes simplex virus ICP27 regulatory protein: importance of the leucine-rich nuclear export signal and RGG Box RNA-binding domain.

Authors:  Joy Lengyel; Chandra Guy; Vivian Leong; Sarah Borge; Stephen A Rice
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

7.  ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export.

Authors:  I-Hsiung Brandon Chen; Ling Li; Lindsey Silva; Rozanne M Sandri-Goldin
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

8.  Role of immediate early protein ICP27 in the differential sensitivity of herpes simplex viruses 1 and 2 to leptomycin B.

Authors:  Donglim Park; Joy Lengyel; Stephen A Rice
Journal:  J Virol       Date:  2013-06-05       Impact factor: 5.103

9.  Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.

Authors:  Danna Hargett; Stephen Rice; Steven L Bachenheimer
Journal:  J Virol       Date:  2006-08-23       Impact factor: 5.103

10.  Rev inhibition strongly affects intracellular distribution of human immunodeficiency virus type 1 RNAs.

Authors:  Dusan Cmarko; Stig-Ove Bøe; Catia Scassellati; Anne Marie Szilvay; Svend Davanger; Xiang-Dong Fu; Gunnar Haukenes; Karl-Henning Kalland; Stanislav Fakan
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103
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