Literature DB >> 11134266

Physiologic and immunologic hurdles to xenotransplantation.

Benjamin Samstein1,2,3, Jeffrey L Platt1.   

Abstract

The major problem in the field of renal transplantation is currently the shortage of available kidneys. However, the use of animals as a source of kidneys, i.e., xenotransplantation, is increasingly being viewed as a potential solution to this problem. One preeminent hurdle to xenotransplantation is the immune response of the recipient against the graft; other hurdles include the physiologic limitations of the transplant, infection, and ethical considerations. This review summarizes what is currently known regarding the obstacles to xenotransplantation and some potential solutions to those problems.

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Year:  2001        PMID： 11134266     DOI： 10.1681/ASN.V121182

Source DB:  PubMed          Journal:  J Am Soc Nephrol        ISSN： 1046-6673            Impact factor:   10.121


  16 in total

1.  Integration of a novel injectable nano calcium sulfate/alginate scaffold and BMP2 gene-modified mesenchymal stem cells for bone regeneration.

Authors:  Xiaoning He; Rosemary Dziak; Keya Mao; Robert Genco; Mark Swihart; Mark Swithart; Chunyi Li; Shuying Yang
Journal:  Tissue Eng Part A       Date:  2012-11-16       Impact factor: 3.845

2.  Icariin combined with human umbilical cord mesenchymal stem cells significantly improve the impaired kidney function in chronic renal failure.

Authors:  Wen Li; Li Wang; Xiaoqian Chu; Huantian Cui; Yuhong Bian
Journal:  Mol Cell Biochem       Date:  2017-01-23       Impact factor: 3.396

3.  Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer.

Authors:  Qingran Kong; Guangzhen Ji; Bingteng Xie; Jingyu Li; Jian Mao; Juan Wang; Shichao Liu; Lin Liu; Zhonghua Liu
Journal:  Stem Cell Rev Rep       Date:  2014-06       Impact factor: 5.739

4.  Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons.

Authors:  Akira Shimizu; Yosuke Hisashi; Kenji Kuwaki; Yau-Lin Tseng; Frank J M F Dor; Stuart L Houser; Simon C Robson; Henk-Jan Schuurman; David K C Cooper; David H Sachs; Kazuhiko Yamada; Robert B Colvin
Journal:  Am J Pathol       Date:  2008-05-08       Impact factor: 4.307

Review 5.  Regeneration and bioengineering of the kidney: current status and future challenges.

Authors:  Marcus Salvatori; Andrea Peloso; Ravi Katari; Giuseppe Orlando
Journal:  Curr Urol Rep       Date:  2014-01       Impact factor: 3.092

6.  Pancreas and kidney transplantation using embryonic donor organs.

Authors:  Marc R Hammerman
Journal:  Organogenesis       Date:  2004-07       Impact factor: 2.500

7.  BMP2 genetically engineered MSCs and EPCs promote vascularized bone regeneration in rat critical-sized calvarial bone defects.

Authors:  Xiaoning He; Rosemary Dziak; Xue Yuan; Keya Mao; Robert Genco; Mark Swihart; Debanjan Sarkar; Chunyi Li; Changdong Wang; Li Lu; Stelios Andreadis; Shuying Yang
Journal:  PLoS One       Date:  2013-04-02       Impact factor: 3.240

8.  Association of telomere instability with senescence of porcine cells.

Authors:  Guangzhen Ji; Kai Liu; Maja Okuka; Na Liu; Lin Liu
Journal:  BMC Cell Biol       Date:  2012-12-15       Impact factor: 4.241

9.  Similarities in the immunoglobulin response and VH gene usage in rhesus monkeys and humans exposed to porcine hepatocytes.

Authors:  Joanne L Zahorsky-Reeves; Clare R Gregory; Donald V Cramer; Insiyyah Y Patanwala; Andrew E Kyles; Dominic C Borie; Mary K Kearns-Jonker
Journal:  BMC Immunol       Date:  2006-03-20       Impact factor: 3.615

10.  Telomere reprogramming and maintenance in porcine iPS cells.

Authors:  Guangzhen Ji; Weimin Ruan; Kai Liu; Fang Wang; Despoina Sakellariou; Jijun Chen; Yang Yang; Maja Okuka; Jianyong Han; Zhonghua Liu; Liangxue Lai; Sarantis Gagos; Lei Xiao; Hongkui Deng; Ning Li; Lin Liu
Journal:  PLoS One       Date:  2013-09-30       Impact factor: 3.240
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