Literature DB >> 11128652

Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication.

R B Perni1, S C Conway, S K Ladner, K Zaifert, M J Otto, R W King.   

Abstract

A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure-activity relationships of this series are discussed.

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Year:  2000        PMID： 11128652     DOI： 10.1016/s0960-894x(00)00544-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  20 in total

1.  Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)beta-L-2',3'-dideoxy-3'-thiacytidine.

Authors:  R W King; S K Ladner; T J Miller; K Zaifert; R B Perni; S C Conway; M J Otto
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

2.  Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores.

Authors:  Andrew D Huber; Dallas L Pineda; Dandan Liu; Kelsey N Boschert; Anna T Gres; Jennifer J Wolf; Emily M Coonrod; Jing Tang; Thomas G Laughlin; Qiongying Yang; Maritza N Puray-Chavez; Juan Ji; Kamalendra Singh; Karen A Kirby; Zhengqiang Wang; Stefan G Sarafianos
Journal:  ACS Infect Dis       Date:  2019-01-14       Impact factor: 5.084

Review 3.  Core protein: A pleiotropic keystone in the HBV lifecycle.

Authors:  Adam Zlotnick; Balasubramanian Venkatakrishnan; Zhenning Tan; Eric Lewellyn; William Turner; Samson Francis
Journal:  Antiviral Res       Date:  2015-06-27       Impact factor: 5.970

4.  Evolution of Intermediates during Capsid Assembly of Hepatitis B Virus with Phenylpropenamide-Based Antivirals.

Authors:  Panagiotis Kondylis; Christopher J Schlicksup; Sarah P Katen; Lye Siang Lee; Adam Zlotnick; Stephen C Jacobson
Journal:  ACS Infect Dis       Date:  2019-02-04       Impact factor: 5.084

5.  Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379.

Authors:  Jan Martin Berke; Pascale Dehertogh; Karen Vergauwen; Wendy Mostmans; Koen Vandyck; Pierre Raboisson; Frederik Pauwels
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

6.  Phase diagrams map the properties of antiviral agents directed against hepatitis B virus core assembly.

Authors:  Lichun Li; Srinivas Reddy Chirapu; M G Finn; Adam Zlotnick
Journal:  Antimicrob Agents Chemother       Date:  2012-12-03       Impact factor: 5.191

7.  Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture.

Authors:  Zhenning Tan; Megan L Maguire; Daniel D Loeb; Adam Zlotnick
Journal:  J Virol       Date:  2013-01-02       Impact factor: 5.103

8.  Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators.

Authors:  Dawei Cai; Xiaohe Wang; Ran Yan; Richeng Mao; Yuanjie Liu; Changhua Ji; Andrea Cuconati; Haitao Guo
Journal:  Antiviral Res       Date:  2016-05-13       Impact factor: 5.970

9.  Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure.

Authors:  Sarah P Katen; Zhenning Tan; Srinivas Reddy Chirapu; M G Finn; Adam Zlotnick
Journal:  Structure       Date:  2013-07-18       Impact factor: 5.006

10.  Characterization of the mode of action of a potent dengue virus capsid inhibitor.

Authors:  Pietro Scaturro; Iuni Margaret Laura Trist; David Paul; Anil Kumar; Eliana G Acosta; Chelsea M Byrd; Robert Jordan; Andrea Brancale; Ralf Bartenschlager
Journal:  J Virol       Date:  2014-07-23       Impact factor: 5.103
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