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Literature DB >> 23208717

Phase diagrams map the properties of antiviral agents directed against hepatitis B virus core assembly.

Lichun Li¹, Srinivas Reddy Chirapu, M G Finn, Adam Zlotnick.

Abstract

Assembly effectors are small molecules that induce inappropriate virus capsid assembly to antiviral effect. To identify attributes of hepatitis B virus (HBV) assembly effectors, assembly reaction products (normal capsid, noncapsid polymer, intermediates, and free dimeric core protein) were quantified in the presence of three experimental effectors: HAP12, HAP13, and AT-130. Effectors bound stoichiometrically to capsid protein polymers, but not free protein. Thermodynamic and kinetic effects, not aberrant assembly, correlate with maximal antiviral activity.

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Year: 2012 PMID： 23208717 PMCID： PMC3591873 DOI： 10.1128/AAC.01766-12

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

29 in total

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Journal: Trends Biotechnol Date: 2003-12 Impact factor: 19.536

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Journal: Biologics Date: 2010-05-25

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Authors: Sarah Katen; Adam Zlotnick
Journal: Methods Enzymol Date: 2009 Impact factor: 1.600

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Authors: Michael Nassal
Journal: Virus Res Date: 2008-03-12 Impact factor: 3.303

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Authors: Fabien Zoulim; Stephen Locarnini
Journal: Gastroenterology Date: 2009-09-06 Impact factor: 22.682

7. Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L.

Authors: Pablo Ceres; Stephen J Stray; Adam Zlotnick
Journal: J Virol Date: 2004-09 Impact factor: 5.103

8. Combination HBV therapy is linked to greater HBV DNA suppression in a cohort of lamivudine-experienced HIV/HBV coinfected individuals.

Authors: Gail V Matthews; Eric Seaberg; Gregory J Dore; Scott Bowden; Sharon R Lewin; Joe Sasadeusz; Pip Marks; Zachary Goodman; Frances H Philp; Yiwei Tang; Stephen Locarnini; Chloe L Thio
Journal: AIDS Date: 2009-08-24 Impact factor: 4.177

9. Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein.

Authors: Sawitree Nangola; Agathe Urvoas; Marie Valerio-Lepiniec; Wannisa Khamaikawin; Supachai Sakkhachornphop; Saw-See Hong; Pierre Boulanger; Philippe Minard; Chatchai Tayapiwatana
Journal: Retrovirology Date: 2012-02-20 Impact factor: 4.602

10. Direct binding of a hepatitis C virus inhibitor to the viral capsid protein.

Authors: Smitha Kota; Virginia Takahashi; Feng Ni; John K Snyder; A Donny Strosberg
Journal: PLoS One Date: 2012-02-28 Impact factor: 3.240

17 in total

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Authors: Panagiotis Kondylis; Christopher J Schlicksup; Nicholas E Brunk; Jinsheng Zhou; Adam Zlotnick; Stephen C Jacobson
Journal: J Am Chem Soc Date: 2018-12-31 Impact factor: 15.419

2. Local Stabilization of Subunit-Subunit Contacts Causes Global Destabilization of Hepatitis B Virus Capsids.

Authors: Christopher John Schlicksup; Patrick Laughlin; Steven Dunkelbarger; Joseph Che-Yen Wang; Adam Zlotnick
Journal: ACS Chem Biol Date: 2020-05-19 Impact factor: 5.100

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Authors: Alexander A Kukreja; Joseph C-Y Wang; Elizabeth Pierson; David Z Keifer; Lisa Selzer; Zhenning Tan; Bogdan Dragnea; Martin F Jarrold; Adam Zlotnick
Journal: J Virol Date: 2014-09-24 Impact factor: 5.103

4. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly.

Authors: Guoyi Wu; Bo Liu; Yingjun Zhang; Jing Li; Alla Arzumanyan; Marcia M Clayton; Raymond F Schinazi; Zhaohe Wang; Siegfried Goldmann; Qingyun Ren; Faxhou Zhang; Mark A Feitelson
Journal: Antimicrob Agents Chemother Date: 2013-08-19 Impact factor: 5.191

Review 5. Core protein: A pleiotropic keystone in the HBV lifecycle.

Authors: Adam Zlotnick; Balasubramanian Venkatakrishnan; Zhenning Tan; Eric Lewellyn; William Turner; Samson Francis
Journal: Antiviral Res Date: 2015-06-27 Impact factor: 5.970

6. Evolution of Intermediates during Capsid Assembly of Hepatitis B Virus with Phenylpropenamide-Based Antivirals.

Authors: Panagiotis Kondylis; Christopher J Schlicksup; Sarah P Katen; Lye Siang Lee; Adam Zlotnick; Stephen C Jacobson
Journal: ACS Infect Dis Date: 2019-02-04 Impact factor: 5.084

7. Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals.

Authors: Lu Ruan; Jodi A Hadden; Adam Zlotnick
Journal: J Virol Date: 2018-09-26 Impact factor: 5.103

8. Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.

Authors: Elena Lomonosova; Adam Zlotnick; John E Tavis
Journal: Antimicrob Agents Chemother Date: 2017-02-23 Impact factor: 5.191

9. A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formation.

Authors: Ya-Juan Wang; Dong Lu; Yi-Bin Xu; Wei-Qiang Xing; Xian-Kun Tong; Gui-Feng Wang; Chun-Lan Feng; Pei-Lan He; Li Yang; Wei Tang; You-Hong Hu; Jian-Ping Zuo
Journal: Antimicrob Agents Chemother Date: 2015-09-08 Impact factor: 5.191

10. Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket.

Authors: Balasubramanian Venkatakrishnan; Sarah P Katen; Samson Francis; Srinivas Chirapu; M G Finn; Adam Zlotnick
Journal: J Virol Date: 2016-03-28 Impact factor: 5.103