| Literature DB >> 11128644 |
A Okazawa1, H Maeda, E Fukusaki, Y Katakura, A Kobayashi.
Abstract
DNA aptamers that bind to hematoporphyrin IX (HPIX) were isolated using an in vitro selection technique. Most aptamers obtained after the 7th and 10th rounds contained guanine-rich sequences. Binding assay using fluorescence polarization technique and structural analysis by CD spectra revealed that the parallel guanine-quartet structure of the aptamer participates in the recognition of HPIX.Entities:
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Year: 2000 PMID: 11128644 DOI: 10.1016/s0960-894x(00)00540-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN: 0960-894X Impact factor: 2.823