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Literature DB >> 11122960

Sexual side effects of antidepressant drugs.

A J Gelenberg¹, P Delgado, H G Nurnberg.

Abstract

Sexual functioning often suffers during depression, although depressed people continue to value sex. Many popular antidepressants further impair sexual functioning, with highly serotonergic agents affecting orgasm and libido prominently. This paper addresses clinical assessment of sexual side effects from antidepressant drugs and reviews treatment strategies, including purported antidotes. We pay particular attention to sildenafil, on which there are impressive data and ongoing controlled studies.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2000 PMID： 11122960 DOI： 10.1007/s11920-996-0012-4

Source DB: PubMed Journal: Curr Psychiatry Rep ISSN： 1523-3812 Impact factor: 5.285

35 in total

1. Sildenafil treatment of serotonin reuptake inhibitor-induced sexual dysfunction.

Authors: A K Ashton; R G Bennett
Journal: J Clin Psychiatry Date: 1999-03 Impact factor: 4.384

2. Treatment-emergent changes in sexual function with selective serotonin reuptake inhibitors as measured with the Rush Sexual Inventory.

Authors: J Zajecka; S Mitchell; J Fawcett
Journal: Psychopharmacol Bull Date: 1997

Review 3. Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors.

Authors: W W Shen; Z Urosevich; D O Clayton
Journal: J Reprod Med Date: 1999-06 Impact factor: 0.142

4. Sildenafil for iatrogenic serotonergic antidepressant medication-induced sexual dysfunction in 4 patients.

Authors: H G Nurnberg; J Lauriello; P L Hensley; L M Parker; S J Keith
Journal: J Clin Psychiatry Date: 1999-01 Impact factor: 4.384

5. Sexual functioning in chronically depressed patients treated with SSRI antidepressants: a pilot study.

Authors: L A Piazza; J C Markowitz; J H Kocsis; A C Leon; L Portera; N L Miller; D Adler
Journal: Am J Psychiatry Date: 1997-12 Impact factor: 18.112

6. The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study.

Authors: A B Araujo; R Durante; H A Feldman; I Goldstein; J B McKinlay
Journal: Psychosom Med Date: 1998 Jul-Aug Impact factor: 4.312

7. Fluoxetine-induced sexual dysfunction.

Authors: J B Herman; A W Brotman; M H Pollack; W E Falk; J Biederman; J F Rosenbaum
Journal: J Clin Psychiatry Date: 1990-01 Impact factor: 4.384

8. Clinician-rated symptoms and signs of depression in aged Finns.

Authors: S L Kivelä; K Pahkala
Journal: Int J Soc Psychiatry Date: 1988

9. Somatic symptoms in primary affective disorder. Presence and relationship to the classification of depression.

Authors: R C Casper; D E Redmond; M M Katz; C B Schaffer; J M Davis; S H Koslow
Journal: Arch Gen Psychiatry Date: 1985-11

10. Sexual function in depressed men. Assessment by self-report, behavioral, and nocturnal penile tumescence measures before and after treatment with cognitive behavior therapy.

Authors: E A Nofzinger; M E Thase; C F Reynolds; E Frank; J R Jennings; G L Garamoni; A L Fasiczka; D J Kupfer
Journal: Arch Gen Psychiatry Date: 1993-01

5 in total

Review 1. Sexual dysfunction and depression.

Authors: S N Seidman; S P Roose
Journal: Curr Psychiatry Rep Date: 2001-06 Impact factor: 5.285