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Literature DB >> 11122802

In vitro chemosensitivity testing and mechanisms of drug resistance.

Abstract

This article reviews the cellular mechanisms that confer biochemical and clinical resistance to antineoplastic agents used in the adjunctive treatment and palliation of metastatic ovarian cancer. The historical development of in vitro chemosensitivity testing is also reviewed, along with published experiences of various investigators with assays used in clinical ovarian cancer treatment programs. Finally, an investigational protocol for chemosensitivity testing is proposed.

Entities: Disease

Mesh：

Year: 1999 PMID： 11122802 DOI： 10.1007/s11912-999-0014-6

Source DB: PubMed Journal: Curr Oncol Rep ISSN： 1523-3790 Impact factor: 5.075

49 in total

1. Further observations on the effects of cancer chemotherapeutic agents on the in vitro dehydrogenase activity of cancer tissue.

Authors: M M BLACK; F D SPEER
Journal: J Natl Cancer Inst Date: 1954-04 Impact factor: 13.506

2. Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.

Authors: P J O'Dwyer; T C Hamilton; R C Young; F P LaCreta; N Carp; K D Tew; K Padavic; R L Comis; R F Ozols
Journal: J Natl Cancer Inst Date: 1992-02-19 Impact factor: 13.506

Review 3. Tumor chemosensitivity and chemoresistance assays.

Authors: E Brown; M Markman
Journal: Cancer Date: 1996-03-15 Impact factor: 6.860

4. Tumor chemosensitivity and chemoresistance assays.

Authors: D H Kern
Journal: Cancer Date: 1997-04-01 Impact factor: 6.860

Review 5. Review of the efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing for patients with cancer.

Authors: P Cortazar; B E Johnson
Journal: J Clin Oncol Date: 1999-05 Impact factor: 44.544

In vitro chemosensitivity testing and mechanisms of drug resistance.

1. Further observations on the effects of cancer chemotherapeutic agents on the in vitro dehydrogenase activity of cancer tissue.

2. Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.

Review 3. Tumor chemosensitivity and chemoresistance assays.

4. Tumor chemosensitivity and chemoresistance assays.

Review 5. Review of the efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing for patients with cancer.

6. Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.

7. Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

8. Bioluminescence of cellular ATP: a new method for evaluating cytotoxic agents in vitro.

9. Importance of multiagent chemotherapy regimens in ovarian carcinoma: dose intensity analysis.

10. The clinical relevance of chemosensitivity testing in ovarian cancer.

Review 1. Methods and goals for the use of in vitro and in vivo chemosensitivity testing.

2. In vitro chemosensitivity in ovarian carcinoma: Comparison of three leading assays.