| Literature DB >> 11120386 |
G A Wasserman1, X Liu, D Popovac, P Factor-Litvak, J Kline, C Waternaux, N LoIacono, J H Graziano.
Abstract
To investigate associations between the timing of lead (Pb) exposure on early intelligence, we examined the results of psychometric evaluations at ages 3, 4, 5, and 7 years, from 442 children whose mothers were recruited during pregnancy from a smelter town and a non-lead-exposed town in Yugoslavia. We compared the relative contribution of prenatal blood lead (BPb) with that of relative increases in BPb in either the early (0-2 years) or the later (from 2 years on) postnatal period to child intelligence measured longitudinally at ages 3 and 4 (McCarthy GCI), 5 (Wechsler Preschool and Primary Scale of Intelligence-Revised, WPPSI-R IQ), and 7 (Wechsler Intelligence Scale for Children-version III, WISC-III IQ), controlling for: Home Observation for Measurement of the Environment (HOME) quality; maternal age, intelligence, education, and ethnicity; and birthweight and gender. Elevations in both prenatal and postnatal BPb were associated with small decrements in young children's intelligence.Entities:
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Year: 2000 PMID： 11120386 DOI： 10.1016/s0892-0362(00)00106-9
Source DB: PubMed Journal: Neurotoxicol Teratol ISSN： 0892-0362 Impact factor: 3.763