Literature DB >> 11119549

Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin.

V Q Nguyen1, R M Caprioli, T L Cover.   

Abstract

The vacA gene of Helicobacter pylori strain 60190 encodes a 1, 287-amino-acid protoxin, which undergoes cleavage of a 33-amino-acid amino-terminal signal sequence and carboxy-terminal proteolytic processing to yield a mature secreted toxin. Several features of VacA suggest that it belongs to the autotransporter family of gram-negative bacterial secreted proteins. Based on matrix-assisted laser desorption ionization-time of flight mass spectrometric analysis, we calculate that the mature toxin has a mass of 88.2+/-0.2 kDa and consists of approximately 821 amino acids.

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Year:  2001        PMID： 11119549      PMCID： PMC97915          DOI： 10.1128/IAI.69.1.543-546.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  Common structural features of IgA1 protease-like outer membrane protein autotransporters.

Authors:  J Jose; F Jähnig; T F Meyer
Journal:  Mol Microbiol       Date:  1995-10       Impact factor: 3.501

2.  Purification and characterization of the vacuolating toxin from Helicobacter pylori.

Authors:  T L Cover; M J Blaser
Journal:  J Biol Chem       Date:  1992-05-25       Impact factor: 5.157

3.  3D imaging of the 58 kDa cell binding subunit of the Helicobacter pylori cytotoxin.

Authors:  J M Reyrat; S Lanzavecchia; P Lupetti; M de Bernard; C Pagliaccia; V Pelicic; M Charrel; C Ulivieri; N Norais; X Ji; V Cabiaux; E Papini; R Rappuoli; J L Telford
Journal:  J Mol Biol       Date:  1999-07-09       Impact factor: 5.469

Review 4.  The secretion pathway of IgA protease-type proteins in gram-negative bacteria.

Authors:  T Klauser; J Pohlner; T F Meyer
Journal:  Bioessays       Date:  1993-12       Impact factor: 4.345

5.  Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease.

Authors:  J Pohlner; R Halter; K Beyreuther; T F Meyer
Journal:  Nature       Date:  1987 Jan 29-Feb 4       Impact factor: 49.962

6.  A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation.

Authors:  A D Vinion-Dubiel; M S McClain; D M Czajkowsky; H Iwamoto; D Ye; P Cao; W Schraw; G Szabo; S R Blanke; Z Shao; T L Cover
Journal:  J Biol Chem       Date:  1999-12-31       Impact factor: 5.157

7.  Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein.

Authors:  W Schmitt; R Haas
Journal:  Mol Microbiol       Date:  1994-04       Impact factor: 3.501

8.  Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

Authors:  T L Cover; M K Tummuru; P Cao; S A Thompson; M J Blaser
Journal:  J Biol Chem       Date:  1994-04-08       Impact factor: 5.157

Review 9.  The vacuolating cytotoxin of Helicobacter pylori.

Authors:  T L Cover
Journal:  Mol Microbiol       Date:  1996-04       Impact factor: 3.501

10.  Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

Authors:  J L Telford; P Ghiara; M Dell'Orco; M Comanducci; D Burroni; M Bugnoli; M F Tecce; S Censini; A Covacci; Z Xiang
Journal:  J Exp Med       Date:  1994-05-01       Impact factor: 14.307
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  37 in total

1.  How the loop and middle regions influence the properties of Helicobacter pylori VacA channels.

Authors:  F Tombola; C Pagliaccia; S Campello; J L Telford; C Montecucco; E Papini; M Zoratti
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

2.  Proteome analysis of secreted proteins of the gastric pathogen Helicobacter pylori.

Authors:  Dirk Bumann; Sevil Aksu; Meike Wendland; Katharina Janek; Uschi Zimny-Arndt; Nicolas Sabarth; Thomas F Meyer; Peter R Jungblut
Journal:  Infect Immun       Date:  2002-07       Impact factor: 3.441

3.  Expression of Helicobacter pylori vacuolating toxin in Escherichia coli.

Authors:  Mark S McClain; Timothy L Cover
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

4.  Comparative analysis of the biochemical and functional properties of C-terminal domains of autotransporters.

Authors:  Elvira Marín; Gustavo Bodelón; Luis Ángel Fernández
Journal:  J Bacteriol       Date:  2010-08-27       Impact factor: 3.490

Review 5.  Interactions between bacterial pathogens and mitochondrial cell death pathways.

Authors:  Thomas Rudel; Oliver Kepp; Vera Kozjak-Pavlovic
Journal:  Nat Rev Microbiol       Date:  2010-09-06       Impact factor: 60.633

6.  Reconstitution of Helicobacter pylori VacA toxin from purified components.

Authors:  Christian González-Rivera; Kelly A Gangwer; Mark S McClain; Ilyas M Eli; Melissa G Chambers; Melanie D Ohi; D Borden Lacy; Timothy L Cover
Journal:  Biochemistry       Date:  2010-07-13       Impact factor: 3.162

Review 7.  Helicobacter pylori VacA and gastric ulcer.

Authors:  Daisuke Shirasaka
Journal:  Int J Hematol       Date:  2006-11       Impact factor: 2.490

Review 8.  Type V protein secretion pathway: the autotransporter story.

Authors:  Ian R Henderson; Fernando Navarro-Garcia; Mickaël Desvaux; Rachel C Fernandez; Dlawer Ala'Aldeen
Journal:  Microbiol Mol Biol Rev       Date:  2004-12       Impact factor: 11.056

9.  Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein.

Authors:  Victor J Torres; Mark S McClain; Timothy L Cover
Journal:  Infect Immun       Date:  2006-04       Impact factor: 3.441

10.  Autoprocessing of the Escherichia coli AIDA-I autotransporter: a new mechanism involving acidic residues in the junction region.

Authors:  Marie-Eve Charbonneau; Julie Janvore; Michael Mourez
Journal:  J Biol Chem       Date:  2009-04-27       Impact factor: 5.157
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