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Literature DB >> 17118757

Helicobacter pylori VacA and gastric ulcer.

Abstract

VacA, the only protein toxin produced by Helicobacter pylori, vacuolates cultured cells. The presence of 2 VacA receptors has been demonstrated. One is the receptor-type protein tyrosine phosphatase (RPTP) zeta/beta (PTP zeta/beta), and the other is RPTP alpha. VacA binds to PTP zeta/beta, resulting in gastric epithelial detachment through the tyrosine phosphorylation of Git-1, which then leads to gastric ulceration by the direct action of gastric acid. Thus, disturbance of adhesion between gastric epithelial cells and the extracellular matrix due to an abnormal PTP zeta/beta signal is the main mechanism of gastric ulceration.

Entities: Chemical Disease Species

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Year: 2006 PMID： 17118757 DOI： 10.1532/IJH97.06154

Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490

19 in total

1. Analysis of Helicobacter pylori vacA gene and serum antibodies to VacA in Japan.

Authors: D Shirasaka; N Aoyama; K Satonaka; K Shirakawa; H Yoshida; T Sakai; T Ikemura; Y Shinoda; M Sakashita; M Miyamoto; K Yahiro; A Wada; H Kurazono; T Hirayama; M Kasuga
Journal: Dig Dis Sci Date: 2000-04 Impact factor: 3.199

2. Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor.

Authors: Kinnosuke Yahiro; Akihiro Wada; Masaaki Nakayama; Takahiro Kimura; Ken-ichi Ogushi; Takuro Niidome; Haruhiko Aoyagi; Ken-ichi Yoshino; Kazuyoshi Yonezawa; Joel Moss; Toshiya Hirayama
Journal: J Biol Chem Date: 2003-03-06 Impact factor: 5.157

3. Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta.

Authors: K Yahiro; T Niidome; M Kimura; T Hatakeyama; H Aoyagi; H Kurazono; K i Imagawa; A Wada; J Moss; T Hirayama
Journal: J Biol Chem Date: 1999-12-17 Impact factor: 5.157

4. Helicobacter pylori vacuolating cytotoxin binds to the 140-kDa protein in human gastric cancer cell lines, AZ-521 and AGS.

Authors: K Yahiro; T Niidome; T Hatakeyama; H Aoyagi; H Kurazono; P I Padilla; A Wada; T Hirayama
Journal: Biochem Biophys Res Commun Date: 1997-09-18 Impact factor: 3.575

5. Purification, characterization and developmental expression of a brain-specific chondroitin sulfate proteoglycan, 6B4 proteoglycan/phosphacan.

Authors: N Maeda; H Hamanaka; A Oohira; M Noda
Journal: Neuroscience Date: 1995-07 Impact factor: 3.590

6. Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system.

Authors: H Kawachi; A Fujikawa; N Maeda; M Noda
Journal: Proc Natl Acad Sci U S A Date: 2001-05-29 Impact factor: 11.205

7. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.

Authors: Akihiro Fujikawa; Daisuke Shirasaka; Shoichi Yamamoto; Hiroyoshi Ota; Kinnosuke Yahiro; Masahide Fukada; Takafumi Shintani; Akihiro Wada; Nobuo Aoyama; Toshiya Hirayama; Hiroshi Fukamachi; Masaharu Noda
Journal: Nat Genet Date: 2003-02-24 Impact factor: 38.330

8. Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene.

Authors: T Shintani; E Watanabe; N Maeda; M Noda
Journal: Neurosci Lett Date: 1998-05-15 Impact factor: 3.046