Literature DB >> 11114748

Tyrosine kinases and gastric cancer.

W Lin1, H W Kao, D Robinson, H J Kung, C W Wu, H C Chen.   

Abstract

Carcinoma of the stomach is one of the most prevalent cancer types in the world today. Two major forms of gastric cancer are distinguished according to their morphological and clinicopathological classifications (well differentiated/intestinal type and poorly differentiated/diffuse type), characteristics that could also be attributed to the altered expression of different types of oncogenes or tumor suppressor genes. Significant differences exist for gastric cancer incidence comparing people of different ethnic origins, implicating various genetic and epigenetic factors for gastric oncogenesis. There are only a limited number of molecular markers available for gastric cancer detection and prognostic evaluation, among which are tyrosine kinases. There is convincing evidence that tyrosine kinases are involved in oncogenesis and disease progression for many human cancers. Amplifications of certain tyrosine kinases (c-met, k-sam and erbB2/neu) have been associated with human gastric cancer progression. Alternatively spliced transcripts and enhanced protein-expression levels for some of these tyrosine kinases are correlated with clinical outcomes for gastric cancer patients. With advent of high throughput techniques, it is now possible to detect nearly all expressed tyrosine kinases in a single screen. This increases the chance to identify additional tyrosine kinases as predictive markers for gastric cancers. In this article, we will first review the literature data concerning certain tyrosine kinases implicated in gastric carcinogenesis and then summarize more recent work which provide comprehensive tyrosine kinase profiles for gastric cancer specimens and cell lines. Two new gastric cancer molecular markers (tie-1 and mkk4) have been identified through the use of these profiles and demonstrated effective as clinical prognostic indicators.

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Year:  2000        PMID: 11114748     DOI: 10.1038/sj.onc.1203924

Source DB:  PubMed          Journal:  Oncogene        ISSN: 0950-9232            Impact factor:   9.867


  25 in total

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Authors:  Chang Geun Kim; Hyemin Lee; Nehal Gupta; Sharavan Ramachandran; Itishree Kaushik; Sangeeta Srivastava; Sung-Hoon Kim; Sanjay K Srivastava
Journal:  Semin Cancer Biol       Date:  2017-08-01       Impact factor: 15.707

2.  Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase.

Authors:  L F Lee; J Guan; Y Qiu; H J Kung
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

Review 3.  Genomic and genetic alterations influence the progression of gastric cancer.

Authors:  Stefania Nobili; Lorenzo Bruno; Ida Landini; Cristina Napoli; Paolo Bechi; Francesco Tonelli; Carlos A Rubio; Enrico Mini; Gabriella Nesi
Journal:  World J Gastroenterol       Date:  2011-01-21       Impact factor: 5.742

4.  Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes.

Authors:  Olena V Bogdanova; Larysa I Kot; Kateryna V Lavrova; Volodymyr B Bogdanov; Erica K Sloan; Tetyana V Beregova; Ludmyla I Ostapchenko
Journal:  World J Biol Chem       Date:  2010-11-26

5.  Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors.

Authors:  Toshiyuki Nakayama; Go Hatachi; Chun-Yang Wen; Ayumi Yoshizaki; Kazuyuki Yamazumi; Daisuke Niino; Ichiro Sekine
Journal:  World J Gastroenterol       Date:  2005-02-21       Impact factor: 5.742

Review 6.  Effect of tyrosine kinase inhibitors on wound healing and tissue repair: implications for surgery in cancer patients.

Authors:  Devron R Shah; Shamik Dholakia; Rashmi R Shah
Journal:  Drug Saf       Date:  2014-03       Impact factor: 5.606

Review 7.  Gene mutations in gastric cancer: a review of recent next-generation sequencing studies.

Authors:  Y Lin; Z Wu; W Guo; J Li
Journal:  Tumour Biol       Date:  2015-09-12

Review 8.  Signalling pathways involved in clinical responses to chemotherapy.

Authors:  R Perona; I Sánchez-Pérez
Journal:  Clin Transl Oncol       Date:  2007-10       Impact factor: 3.405

9.  Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.

Authors:  Mariko Oki; Hiroyuki Yamamoto; Hiroaki Taniguchi; Yasushi Adachi; Kohzoh Imai; Yasuhisa Shinomura
Journal:  World J Gastroenterol       Date:  2008-10-07       Impact factor: 5.742

10.  ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells.

Authors:  G Valabrega; F Fagioli; S Corso; E Madon; A Brach del Prever; E Biasin; A Linari; M Aglietta; S Giordano
Journal:  Br J Cancer       Date:  2003-02-10       Impact factor: 7.640

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