BACKGROUND AND OBJECTIVES: In adult acute myeloid leukemia (AML), a variety of clinical and biological parameters have been examined for their potential value in predicting treatment response. Early response to induction therapy could be an important prognostic factor in this disease. DESIGN AND METHODS: We studied the relationship between reduced blasts in bone marrow aspirate on the 14th day (BMA14th) of induction chemotherapy and treatment outcome in 198 adult AML patients of whom 124 were < 60 years old (group A) and 74 > or = 60 years old (group B). Receiver operating characteristic curve analysis was used to assess the prognostic performance of BMA14th. Using the percentages of blasts of < or = 22% and < or = 15% as criteria for predicting treatment outcome gave the highest accuracy in terms of sensitivity and specificity in groups A and B, respectively. RESULTS: In group A, of 97 patients with a BMA14th < or = 22%, 77 (79%) achieved complete remission (CR), whereas of 27 patients with a BMA14th > 22%, 22 (81%) were non-responders (NR) (p < 0.0001). The test sensitivity and specificity were 93.9% and 71.4%, respectively. In group B, of 27 patients with a BMA14th < or = 15%, 18 (67%) achieved CR, whereas of 47 patients with a BMA14th >15%, 38 (81%) were NR (p = 0.0001). The test sensitivity and specificity were 66.7% and 80.9%, respectively. INTERPRETATION AND CONCLUSIONS: Our data suggest that BMA14th may be a predictive test for CR, helping to identify NR patients early in their disease. Further studies are needed to establish the practical implications of the results of our study.
BACKGROUND AND OBJECTIVES: In adult acute myeloid leukemia (AML), a variety of clinical and biological parameters have been examined for their potential value in predicting treatment response. Early response to induction therapy could be an important prognostic factor in this disease. DESIGN AND METHODS: We studied the relationship between reduced blasts in bone marrow aspirate on the 14th day (BMA14th) of induction chemotherapy and treatment outcome in 198 adult AMLpatients of whom 124 were < 60 years old (group A) and 74 > or = 60 years old (group B). Receiver operating characteristic curve analysis was used to assess the prognostic performance of BMA14th. Using the percentages of blasts of < or = 22% and < or = 15% as criteria for predicting treatment outcome gave the highest accuracy in terms of sensitivity and specificity in groups A and B, respectively. RESULTS: In group A, of 97 patients with a BMA14th < or = 22%, 77 (79%) achieved complete remission (CR), whereas of 27 patients with a BMA14th > 22%, 22 (81%) were non-responders (NR) (p < 0.0001). The test sensitivity and specificity were 93.9% and 71.4%, respectively. In group B, of 27 patients with a BMA14th < or = 15%, 18 (67%) achieved CR, whereas of 47 patients with a BMA14th >15%, 38 (81%) were NR (p = 0.0001). The test sensitivity and specificity were 66.7% and 80.9%, respectively. INTERPRETATION AND CONCLUSIONS: Our data suggest that BMA14th may be a predictive test for CR, helping to identify NR patients early in their disease. Further studies are needed to establish the practical implications of the results of our study.
Authors: Nicholas J Short; Hagop M Kantarjian; Koji Sasaki; Jorge E Cortes; Farhad Ravandi; Deborah A Thomas; Guillermo Garcia-Manero; Issa Khouri; Partow Kebriaei; Richard E Champlin; Sherry Pierce; Ghayas C Issa; Marina Konopleva; Tapan M Kadia; Carlos Bueso-Ramos; Joseph D Khoury; Nitin Jain; Susan M O'Brien; Elias Jabbour Journal: Cancer Date: 2016-08-10 Impact factor: 6.860
Authors: Roger S Riley; Thomas F Hogan; Dawn R Pavot; Robert Forysthe; Davis Massey; Eileen Smith; Lou Wright; Jonathan M Ben-Ezra Journal: J Clin Lab Anal Date: 2004 Impact factor: 2.352
Authors: Sarah Bertoli; Pierre Bories; Marie C Béné; Sylvie Daliphard; Bruno Lioure; Arnaud Pigneux; Norbert Vey; Jacques Delaunay; Vincent Leymarie; Isabelle Luquet; Odile Blanchet; Pascale Cornillet-Lefebvre; Mathilde Hunault; Didier Bouscary; Nathalie Fegueux; Philippe Guardiola; François Dreyfus; Jean Luc Harousseau; Jean Yves Cahn; Norbert Ifrah; Christian Récher Journal: Haematologica Date: 2013-08-23 Impact factor: 9.941
Authors: João Tadeu D Souto Filho; Monique M Loureiro; Wolmar Pulcheri; José Carlos Morais; Marcio Nucci; Rodrigo D Portugal Journal: Diagn Pathol Date: 2015-07-25 Impact factor: 2.644