Literature DB >> 11112637

Synthesis of the sialidase inhibitor siastatin B.

S Knapp1, D Zhao.   

Abstract

[structure] The resolved piperidinecarboxylate (R)-7 was converted to siastatin B (1) by an efficient and stereoselective sequence that includes a bromo-beta-lactonization and an N-acyliminium azidation. Two analogues (3 and 4) of siastatin were also prepared.

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Year:  2000        PMID： 11112637     DOI： 10.1021/ol0066680

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  NanI Sialidase Can Support the Growth and Survival of Clostridium perfringens Strain F4969 in the Presence of Sialyated Host Macromolecules (Mucin) or Caco-2 Cells.

Authors:  Jihong Li; Bruce A McClane
Journal:  Infect Immun       Date:  2018-01-22       Impact factor: 3.441

Review 2.  Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets.

Authors:  Jihong Li; Francisco A Uzal; Bruce A McClane
Journal:  Toxins (Basel)       Date:  2016-11-19       Impact factor: 4.546

3.  Novel pH-dependent regulation of human cytosolic sialidase 2 (NEU2) activities by siastatin B and structural prediction of NEU2/siastatin B complex.

Authors:  M Motiur Rahman; Takatsugu Hirokawa; Daisuke Tsuji; Jun Tsukimoto; Seiji Hitaoka; Tatsusada Yoshida; Hiroshi Chuman; Kohji Itoh
Journal:  Biochem Biophys Rep       Date:  2015-09-25

4.  A Simple Zinc-Mediated Method for Selenium Addition to Michael Acceptors.

Authors:  Francesca Giulia Nacca; Bonifacio Monti; Eder João Lenardão; Paul Evans; Claudio Santi
Journal:  Molecules       Date:  2020-04-26       Impact factor: 4.411

Review 5.  Anti-influenza virus agents: synthesis and mode of action.

Authors:  Irene M Lagoja; Erik De Clercq
Journal:  Med Res Rev       Date:  2008-01       Impact factor: 12.944
  5 in total

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