Literature DB >> 11109025

Scanning of five chromosomes for alcohol consumption loci.

C Vadasz1, M Saito, B Gyetvai, E Mikics, C Vadasz1.   

Abstract

In our present genetic study to map Quantitative Trait Loci (QTLs) for alcohol-related behaviors, we used 44 B6.C and 36 B6.I inbred congenic Recombinant QTL Introgression (RQI) mouse strains of the b5i7 series carrying genes of BALB/cJ (C) or CXBI (I) origin on C57BL/6ByJ (B6) genetic background. Ethyl alcohol consumption (EAC) was measured in adult males, and chromosomes 1, 2, 3, 9, and 15 were scanned with polymorphic microsatellite markers. In the B6.C set of strains, multiple regression analysis yielded a model with three microsatellite markers, which explained 32% of the genetic variance (p=0.0006). The two markers with the highest significance levels in the model, D1Mit167 and D2Mit74, have been mapped to chromosome regions close to the gene opioid receptor kappa 1 (chr. 1) and opioid receptor kappa 3 (chr. 2), respectively. The results of this gene-mapping study suggest that genetic polymorphisms in kappa opioid receptors may contribute to genetic predisposition to voluntary alcohol-drinking behavior.

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Year:  2000        PMID： 11109025     DOI： 10.1016/s0741-8329(00)00098-7

Source DB:  PubMed          Journal:  Alcohol        ISSN： 0741-8329            Impact factor:   2.405


  10 in total

Review 1.  The nature and identification of quantitative trait loci: a community's view.

Authors:  Oduola Abiola; Joe M Angel; Philip Avner; Alexander A Bachmanov; John K Belknap; Beth Bennett; Elizabeth P Blankenhorn; David A Blizard; Valerie Bolivar; Gundrun A Brockmann; Kari J Buck; Jean-Francoise Bureau; William L Casley; Elissa J Chesler; James M Cheverud; Gary A Churchill; Melloni Cook; John C Crabbe; Wim E Crusio; Ariel Darvasi; Gerald de Haan; Peter Dermant; R W Doerge; Rosemary W Elliot; Charles R Farber; Lorraine Flaherty; Jonathan Flint; Howard Gershenfeld; John P Gibson; Jing Gu; Weikuan Gu; Heinz Himmelbauer; Robert Hitzemann; Hui-Chen Hsu; Kent Hunter; Fuad F Iraqi; Ritsert C Jansen; Thomas E Johnson; Byron C Jones; Gerd Kempermann; Frank Lammert; Lu Lu; Kenneth F Manly; Douglas B Matthews; Juan F Medrano; Margarete Mehrabian; Guy Mittlemann; Beverly A Mock; Jeffrey S Mogil; Xavier Montagutelli; Grant Morahan; John D Mountz; Hiroki Nagase; Richard S Nowakowski; Bruce F O'Hara; Alexander V Osadchuk; Beverly Paigen; Abraham A Palmer; Jeremy L Peirce; Daniel Pomp; Michael Rosemann; Glenn D Rosen; Leonard C Schalkwyk; Ze'ev Seltzer; Stephen Settle; Kazuhiro Shimomura; Siming Shou; James M Sikela; Linda D Siracusa; Jimmy L Spearow; Cory Teuscher; David W Threadgill; Linda A Toth; Ayo A Toye; Csaba Vadasz; Gary Van Zant; Edward Wakeland; Robert W Williams; Huang-Ge Zhang; Fei Zou
Journal:  Nat Rev Genet       Date:  2003-11       Impact factor: 53.242

Review 2.  Pharmacogenetic studies of alcohol self-administration and withdrawal.

Authors:  John C Crabbe; Tamara J Phillips
Journal:  Psychopharmacology (Berl)       Date:  2003-10-09       Impact factor: 4.530

3.  Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.

Authors:  Huiping Zhang; Fan Wang; Henry R Kranzler; Raymond F Anton; Joel Gelernter
Journal:  Behav Brain Funct       Date:  2012-05-16       Impact factor: 3.759

4.  The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.

Authors:  H Zhang; H R Kranzler; B-Z Yang; X Luo; J Gelernter
Journal:  Mol Psychiatry       Date:  2007-07-10       Impact factor: 15.992

5.  Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.

Authors:  Csaba Vadasz; Mariko Saito; Beatrix M Gyetvai; Melinda Oros; Istvan Szakall; Krisztina M Kovacs; Vidudala V T S Prasad; Grant Morahan; Reka Toth
Journal:  Neurochem Res       Date:  2007-02-02       Impact factor: 3.996

6.  Ventral tegmental transcriptome response to intermittent nicotine treatment and withdrawal in BALB/cJ, C57BL/6ByJ, and quasi-congenic RQI mice.

Authors:  Csaba Vadasz; Mariko Saito; Danielle O'Brien; Jiri Zavadil; Grant Morahan; Goutam Chakraborty; Ray Wang
Journal:  Neurochem Res       Date:  2007-03       Impact factor: 3.996

7.  Genetic analysis of alcohol intake in recombinant inbred and congenic strains derived from A/J and C57BL/6J progenitors.

Authors:  Kathryn Gill; Alan E Boyle
Journal:  Mamm Genome       Date:  2005-05       Impact factor: 2.957

8.  Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.

Authors:  K Yaragudri Vinod; Ratnakumar Yalamanchili; Panayotis K Thanos; Csaba Vadasz; Thomas B Cooper; Nora D Volkow; Basalingappa L Hungund
Journal:  Synapse       Date:  2008-08       Impact factor: 2.562

9.  Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression.

Authors:  Mariko Saito; Danielle O'Brien; Krisztina M Kovacs; Ray Wang; Jiri Zavadil; Csaba Vadasz
Journal:  Neurochem Res       Date:  2005-08       Impact factor: 4.414

10.  Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran.

Authors:  Sara Soleimani Asl; Amir Roointan; Hugo Bergen; Shayan Amiri; Parastoo Mardani; Niloufar Ashtari; Ronak Shabani; Mehdi Mehdizadeh
Journal:  Basic Clin Neurosci       Date:  2018 Mar-Apr
  10 in total

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