Literature DB >> 14634638

The nature and identification of quantitative trait loci: a community's view.

Oduola Abiola, Joe M Angel, Philip Avner, Alexander A Bachmanov, John K Belknap, Beth Bennett, Elizabeth P Blankenhorn, David A Blizard, Valerie Bolivar, Gundrun A Brockmann, Kari J Buck, Jean-Francoise Bureau, William L Casley, Elissa J Chesler, James M Cheverud, Gary A Churchill, Melloni Cook, John C Crabbe, Wim E Crusio, Ariel Darvasi, Gerald de Haan, Peter Dermant, R W Doerge, Rosemary W Elliot, Charles R Farber, Lorraine Flaherty, Jonathan Flint, Howard Gershenfeld, John P Gibson, Jing Gu, Weikuan Gu, Heinz Himmelbauer, Robert Hitzemann, Hui-Chen Hsu, Kent Hunter, Fuad F Iraqi, Ritsert C Jansen, Thomas E Johnson, Byron C Jones, Gerd Kempermann, Frank Lammert, Lu Lu, Kenneth F Manly, Douglas B Matthews, Juan F Medrano, Margarete Mehrabian, Guy Mittlemann, Beverly A Mock, Jeffrey S Mogil, Xavier Montagutelli, Grant Morahan, John D Mountz, Hiroki Nagase, Richard S Nowakowski, Bruce F O'Hara, Alexander V Osadchuk, Beverly Paigen, Abraham A Palmer, Jeremy L Peirce, Daniel Pomp, Michael Rosemann, Glenn D Rosen, Leonard C Schalkwyk, Ze'ev Seltzer, Stephen Settle, Kazuhiro Shimomura, Siming Shou, James M Sikela, Linda D Siracusa, Jimmy L Spearow, Cory Teuscher, David W Threadgill, Linda A Toth, Ayo A Toye, Csaba Vadasz, Gary Van Zant, Edward Wakeland, Robert W Williams, Huang-Ge Zhang, Fei Zou.   

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Keywords:  Non-programmatic

Mesh:

Year:  2003        PMID: 14634638      PMCID: PMC2063446          DOI: 10.1038/nrg1206

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  34 in total

1.  An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells.

Authors:  Jay L Vivian; Yijing Chen; Della Yee; Elizabeth Schneider; Terry Magnuson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-13       Impact factor: 11.205

2.  Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines.

Authors:  Beth Bennett; Mary Beeson; Lena Gordon; Phyllis Carosone-Link; Thomas E Johnson
Journal:  Alcohol Clin Exp Res       Date:  2002-11       Impact factor: 3.455

3.  Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice.

Authors:  Christina K Haston; Colin McKerlie; Susan Newbigging; Mary Corey; Richard Rozmahel; Lap-Chee Tsui
Journal:  Mamm Genome       Date:  2002-11       Impact factor: 2.957

4.  Experimental designs for QTL fine mapping in rodents.

Authors:  Anne Shalom; Ariel Darvasi
Journal:  Methods Mol Biol       Date:  2002

5.  From QTL to gene: the harvest begins.

Authors:  Ron Korstanje; Beverly Paigen
Journal:  Nat Genet       Date:  2002-07       Impact factor: 38.330

Review 6.  Enabling population and quantitative genomics.

Authors:  Greg Gibson; Trudy F C Mackay
Journal:  Genet Res       Date:  2002-08       Impact factor: 1.588

Review 7.  Finding genes that underlie complex traits.

Authors:  Anne M Glazier; Joseph H Nadeau; Timothy J Aitman
Journal:  Science       Date:  2002-12-20       Impact factor: 47.728

8.  Permutation tests for multiple loci affecting a quantitative character.

Authors:  R W Doerge; G A Churchill
Journal:  Genetics       Date:  1996-01       Impact factor: 4.562

9.  Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.

Authors:  Christoph Fehr; Renee L Shirley; John K Belknap; John C Crabbe; Kari J Buck
Journal:  J Neurosci       Date:  2002-05-01       Impact factor: 6.167

10.  A highly efficient recombineering-based method for generating conditional knockout mutations.

Authors:  Pentao Liu; Nancy A Jenkins; Neal G Copeland
Journal:  Genome Res       Date:  2003-03       Impact factor: 9.043

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  159 in total

1.  Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.

Authors:  Zhimin Zhang; Jessica S Rowlan; Qian Wang; Weibin Shi
Journal:  Circ Cardiovasc Genet       Date:  2012-01-31

2.  Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11.

Authors:  Charles R Farber; Juan F Medrano
Journal:  Genetics       Date:  2006-11-16       Impact factor: 4.562

3.  Mapping quantitative trait loci in multiple populations of Arabidopsis thaliana identifies natural allelic variation for trichome density.

Authors:  V Vaughan Symonds; A Veronica Godoy; Teresa Alconada; Javier F Botto; Thomas E Juenger; Jorge J Casal; Alan M Lloyd
Journal:  Genetics       Date:  2005-01-16       Impact factor: 4.562

4.  Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping.

Authors:  Renhua Li; Malcolm A Lyons; Henning Wittenburg; Beverly Paigen; Gary A Churchill
Journal:  Genetics       Date:  2005-01-16       Impact factor: 4.562

5.  Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.

Authors:  Luanne L Peters; Weidong Zhang; Amy J Lambert; Carlo Brugnara; Gary A Churchill; Orah S Platt
Journal:  Mamm Genome       Date:  2005-10-29       Impact factor: 2.957

Review 6.  Natural variation in Arabidopsis. How do we find the causal genes?

Authors:  Detlef Weigel; Magnus Nordborg
Journal:  Plant Physiol       Date:  2005-06       Impact factor: 8.340

7.  Quantitative trait locus (QTL) isogenic recombinant analysis: a method for high-resolution mapping of QTL within a single population.

Authors:  Johan D Peleman; Crispin Wye; Jan Zethof; Anker P Sørensen; Henk Verbakel; Jan van Oeveren; Tom Gerats; Jeroen Rouppe van der Voort
Journal:  Genetics       Date:  2005-08-05       Impact factor: 4.562

Review 8.  After GWAS: mice to the rescue?

Authors:  Joerg Ermann; Laurie H Glimcher
Journal:  Curr Opin Immunol       Date:  2012-09-29       Impact factor: 7.486

9.  Gene expression differences in mice divergently selected for methamphetamine sensitivity.

Authors:  Abraham A Palmer; Miguel Verbitsky; Rathi Suresh; Helen M Kamens; Cheryl L Reed; Na Li; Sue Burkhart-Kasch; Carrie S McKinnon; John K Belknap; T Conrad Gilliam; Tamara J Phillips
Journal:  Mamm Genome       Date:  2005-05       Impact factor: 2.957

10.  Identification of QTLs associated with resistance to soybean cyst nematode races 2, 3 and 5 in soybean PI 90763.

Authors:  B Guo; D A Sleper; P R Arelli; J G Shannon; H T Nguyen
Journal:  Theor Appl Genet       Date:  2005-10-18       Impact factor: 5.699

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