BACKGROUND: EPH family receptor tyrosine kinases and their ligand ephrins play pivotal roles in development. High-level expression of transcripts encoding EPHB6 receptors (EPHB6), its ligands ephrin-B2 and ephrin-B3 (EFNB2, EFNB3) is predictive of favorable disease outcome of neuroblastoma (NB). When combined with TrkA expression, the expression of EPHB6, EFNB2, or EFNB3 predicts more accurately the disease outcome than each of the four variables alone. PROCEDURE: Cox regression and Kaplan-Meier analyses were used to assess the prognostic significance of EPHB6, EFNB2, EFNB3, and TrkA expressions in NB without MYCN amplification. RESULTS: High-level expression of EFNB3 or TrkA predicted favorable NB outcome of NB without MYCN amplification (p < 0.03). As found in the general NB population, EPHB6, EFNB2, or EFNB3 expression in combination with TrkA expression was significantly predictive of the disease outcome of normal MYCN NB (p < 0.01). CONCLUSIONS: EPHB6, EFNB2, and EFNB3 expressions may permit further refinement of the prognostic stratification of NB into favorable and unfavorable groups. Copyright 2000 Wiley-Liss, Inc.
BACKGROUND: EPH family receptor tyrosine kinases and their ligand ephrins play pivotal roles in development. High-level expression of transcripts encoding EPHB6 receptors (EPHB6), its ligands ephrin-B2 and ephrin-B3 (EFNB2, EFNB3) is predictive of favorable disease outcome of neuroblastoma (NB). When combined with TrkA expression, the expression of EPHB6, EFNB2, or EFNB3 predicts more accurately the disease outcome than each of the four variables alone. PROCEDURE: Cox regression and Kaplan-Meier analyses were used to assess the prognostic significance of EPHB6, EFNB2, EFNB3, and TrkA expressions in NB without MYCN amplification. RESULTS: High-level expression of EFNB3 or TrkA predicted favorable NB outcome of NB without MYCN amplification (p < 0.03). As found in the general NB population, EPHB6, EFNB2, or EFNB3 expression in combination with TrkA expression was significantly predictive of the disease outcome of normal MYCN NB (p < 0.01). CONCLUSIONS:EPHB6, EFNB2, and EFNB3 expressions may permit further refinement of the prognostic stratification of NB into favorable and unfavorable groups. Copyright 2000 Wiley-Liss, Inc.
Authors: L J Ricks-Santi; V Apprey; T Mason; B Wilson; M Abbas; W Hernandez; S Hooker; M Doura; G Bonney; G Dunston; R Kittles; C Ahaghotu Journal: Prostate Cancer Prostatic Dis Date: 2012-07-17 Impact factor: 5.554
Authors: James M Paul; Behzad Toosi; Frederick S Vizeacoumar; Kalpana Kalyanasundaram Bhanumathy; Yue Li; Courtney Gerger; Amr El Zawily; Tanya Freywald; Deborah H Anderson; Darrell Mousseau; Rani Kanthan; Zhaolei Zhang; Franco J Vizeacoumar; Andrew Freywald Journal: Oncotarget Date: 2016-08-02
Authors: Behzad M Toosi; Amr El Zawily; Luke Truitt; Matthew Shannon; Odette Allonby; Mohan Babu; John DeCoteau; Darrell Mousseau; Mohsin Ali; Tanya Freywald; Amanda Gall; Frederick S Vizeacoumar; Morgan W Kirzinger; C Ronald Geyer; Deborah H Anderson; TaeHyung Kim; Alana L Welm; Peter Siegel; Franco J Vizeacoumar; Anthony Kusalik; Andrew Freywald Journal: Oncogene Date: 2018-04-27 Impact factor: 9.867