Literature DB >> 11105571

Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium.

C N Wang, Y J Shiao, Y H Kuo, C C Chen, Y L Lin.   

Abstract

A series of polyacetylenes, falcarinone, panaxynol, falcarindiol, panaxydol, and panaxytriol, were isolated from Saposhnikovia divaricata (Turcz.) Schischk and Panax quinquefolium L. These polyacetylenes were identified as active principles on the inhibition of nitrite production by inducible nitric oxide synthase (iNOS). Treatment with 10 microM of panaxynol, falcarindiol, panaxydol and panaxytriol decreased the LPS/IFN-gamma-stimulated accumulation of nitrite by 71.92 +/- 3.07, 69.95 +/- 3.68, 45.48 +/- 6.11 and 36.85 +/- 8.80%, respectively. The IC50 value of falcarinone, panaxynol, falcarindiol, panaxydol and panaxytriol was > 20, 2.23, 1.98, 6.58 and 9.85 microM, respectively.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11105571     DOI： 10.1055/s-2000-8624

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  6 in total

1.  Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes.

Authors:  Young-Ji Shiao; Yun-Lian Lin; Ya-Hui Sun; Chih-Wen Chi; Chieh-Fu Chen; Chuen-Neu Wang
Journal:  Br J Pharmacol       Date:  2005-01       Impact factor: 8.739

2.  Prim-O-glucosylcimifugin Attenuates Lipopolysaccharideinduced Inflammatory Response in RAW 264.7 Macrophages.

Authors:  Jie Zhou; Yuan-Yuan Sun; Meng-Yao Sun; Wei-An Mao; Li Wang; Jian Zhang; Hong Zhang
Journal:  Pharmacogn Mag       Date:  2017-07-19       Impact factor: 1.085

3.  Toxicological Evaluation of Saposhnikoviae Radix Water Extract and its Antihyperuricemic Potential.

Authors:  Chang Won Kim; Jae Hyuck Sung; Jeong Eun Kwon; Hyeon Yeol Ryu; Kyung Seuk Song; Jin Kyu Lee; Sung Ryul Lee; Se Chan Kang
Journal:  Toxicol Res       Date:  2019-10-15

4.  Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica.

Authors:  Young Sun Lee; Jae Ha Yang; Man Jong Bae; Wang Keun Yoo; Shen Ye; Charlie C L Xue; Chun Guang Li
Journal:  Evid Based Complement Alternat Med       Date:  2008-06-12       Impact factor: 2.629

5.  Fallopia japonica, a Natural Modulator, Can Overcome Multidrug Resistance in Cancer Cells.

Authors:  Safaa Yehia Eid; Mahmoud Zaki El-Readi; Mohamed Lotfy Ashour; Michael Wink
Journal:  Evid Based Complement Alternat Med       Date:  2015-08-06       Impact factor: 2.629

6.  Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice.

Authors:  Anusha Chaparala; Deepak Poudyal; Hossam Tashkandi; Erin E Witalison; Alexander A Chumanevich; Jenna L Hofseth; Ivy Nguyen; Olivia Hardy; Douglas L Pittman; Michael D Wyatt; Anthony Windust; Elizabeth A Murphy; Mitzi Nagarkatti; Prakash Nagarkatti; Lorne J Hofseth
Journal:  Oncotarget       Date:  2020-06-02
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.