Literature DB >> 11092972

A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma.

K Okimoto1, M Kouchi, E Kikawa, K Toyosawa, T Koujitani, K Tanaka, N Matsuoka, J Sakurai, O Hino.   

Abstract

A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan, and named the rising "Nihon" rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL, and c-Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs.

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Year:  2000        PMID： 11092972      PMCID： PMC5926279          DOI： 10.1111/j.1349-7006.2000.tb00890.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  10 in total

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Journal:  Prog Exp Tumor Res       Date:  1999

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Journal:  J Urol       Date:  1997-07       Impact factor: 7.450

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Authors:  N Satake; T Kobayashi; E Kobayashi; K Izumi; O Hino
Journal:  Cancer Res       Date:  1999-02-15       Impact factor: 12.701

4.  Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.

Authors:  N Satake; S Urakami; Y Hirayama; K Izumi; O Hino
Journal:  Int J Cancer       Date:  1998-09-11       Impact factor: 7.396

5.  A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.

Authors:  T Kobayashi; Y Hirayama; E Kobayashi; Y Kubo; O Hino
Journal:  Nat Genet       Date:  1995-01       Impact factor: 38.330

6.  Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome.

Authors:  J I Everitt; T L Goldsworthy; D C Wolf; C L Walker
Journal:  J Urol       Date:  1992-12       Impact factor: 7.450

7.  The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene.

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Journal:  Biochem Biophys Res Commun       Date:  1994-09-15       Impact factor: 3.575

8.  Intragenic Tsc2 somatic mutations as Knudson's second hit in spontaneous and chemically induced renal carcinomas in the Eker rat model.

Authors:  T Kobayashi; S Urakami; Y Hirayama; T Yamamoto; M Nishizawa; T Takahara; Y Kubo; O Hino
Journal:  Jpn J Cancer Res       Date:  1997-03

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Journal:  Jpn J Cancer Res       Date:  1995-10

10.  A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat.

Authors:  O Hino; H Mitani; M Nishizawa; H Katsuyama; E Kobayashi; Y Hirayama
Journal:  Jpn J Cancer Res       Date:  1993-11
  10 in total
  11 in total

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Authors:  Ming-Hui Wei; Patrick W Blake; Julia Shevchenko; Jorge R Toro
Journal:  Hum Mutat       Date:  2009-09       Impact factor: 4.878

2.  Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumours in patients.

Authors:  Chiara Grisanzio; Apryle Seeley; Michelle Chang; Michael Collins; Arianna Di Napoli; Su-Chun Cheng; Andrew Percy; Rameen Beroukhim; Sabina Signoretti
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3.  Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome.

Authors:  Laura S Schmidt; Michael L Nickerson; Michelle B Warren; Gladys M Glenn; Jorge R Toro; Maria J Merino; Maria L Turner; Peter L Choyke; Nirmala Sharma; James Peterson; Patrick Morrison; Eamonn R Maher; McClellan M Walther; Berton Zbar; W Marston Linehan
Journal:  Am J Hum Genet       Date:  2005-04-25       Impact factor: 11.025

4.  Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dubé syndrome.

Authors:  Mami Kouchi; Kazuo Okimoto; Izumi Matsumoto; Kohji Tanaka; Masashi Yasuba; Okio Hino
Journal:  Virchows Arch       Date:  2006-01-31       Impact factor: 4.064

Review 5.  Choosing The Right Animal Model for Renal Cancer Research.

Authors:  Paweł Sobczuk; Anna Brodziak; Mohammed Imran Khan; Stuti Chhabra; Michał Fiedorowicz; Marlena Wełniak-Kamińska; Kamil Synoradzki; Ewa Bartnik; Agnieszka Cudnoch-Jędrzejewska; Anna M Czarnecka
Journal:  Transl Oncol       Date:  2020-02-22       Impact factor: 4.243

6.  A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer.

Authors:  Kazuo Okimoto; Junko Sakurai; Toshiyuki Kobayashi; Hiroaki Mitani; Youko Hirayama; Michael L Nickerson; Michelle B Warren; Berton Zbar; Laura S Schmidt; Okio Hino
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-09       Impact factor: 11.205

7.  Spontaneous occurrence of a distinctive renal tubule tumor phenotype in rat carcinogenicity studies conducted by the national toxicology program.

Authors:  Gordon C Hard; John Curtis Seely; Grace E Kissling; Laura J Betz
Journal:  Toxicol Pathol       Date:  2008-04-25       Impact factor: 1.902

8.  Cystic cholangioma in the thoracic cavity of a rat.

Authors:  Yoshiko Michimae; Kazuo Okimoto; Kaoru Toyosawa; Izumi Matsumoto; Mami Kouchi; Tomoaki Tochitani; Takatoshi Koujitani; Hitoshi Funabashi; Takaki Seki
Journal:  J Toxicol Pathol       Date:  2012-03       Impact factor: 1.628

9.  Spontaneous renal tumors suspected of being familial in sprague-dawley rats.

Authors:  Kayoko Kudo; Toru Hoshiya; Tomomi Nakazawa; Tsubasa Saito; Natsumi Shimoyama; Isamu Suzuki; Kazutoshi Tamura; John Curtis Seely
Journal:  J Toxicol Pathol       Date:  2012-12-20       Impact factor: 1.628

Review 10.  BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reports.

Authors:  J R Toro; M-H Wei; G M Glenn; M Weinreich; O Toure; C Vocke; M Turner; P Choyke; M J Merino; P A Pinto; S M Steinberg; L S Schmidt; W M Linehan
Journal:  J Med Genet       Date:  2008-01-30       Impact factor: 6.318
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