Literature DB >> 7916573

The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene.

O Hino1, T Kobayashi, H Tsuchiya, Y Kikuchi, E Kobayashi, H Mitani, Y Hirayama.   

Abstract

The Eker rat is a promising animal model of cancer predisposition syndromes. In this study, using 129 backcross animals, we have established a new conserved linkage group on rat 10q and human 16p13.3 whereby the Eker mutation was found to be tightly linked to the tuberous sclerosis (TSC2) gene. This will be the first step toward the positional cloning and identification of the predisposing Eker mutation.

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Year:  1994        PMID： 7916573     DOI： 10.1006/bbrc.1994.2324

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  20 in total

1.  Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog.

Authors:  T Kobayashi; S Urakami; J P Cheadle; R Aspinwall; P Harris; J R Sampson; O Hino
Journal:  Mamm Genome       Date:  1997-08       Impact factor: 2.957

2.  A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.

Authors:  T Kobayashi; O Minowa; Y Sugitani; S Takai; H Mitani; E Kobayashi; T Noda; O Hino
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

3.  Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3.

Authors:  J S Simon; G Deshmukh; F J Couch; S D Merajver; B L Weber; P Van Vooren; F Tissil; J Szpirer; C Szpirer; S L Alper; H J Jacob; F C Brosius
Journal:  Mamm Genome       Date:  1996-05       Impact factor: 2.957

4.  Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene.

Authors:  T Kobayashi; H Mitani; R Takahashi; M Hirabayashi; M Ueda; H Tamura; O Hino
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

5.  Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.

Authors:  T J Jónasdóttir; C S Mellersh; L Moe; R Heggebø; H Gamlem; E A Ostrander; F Lingaas
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

Review 6.  Choosing The Right Animal Model for Renal Cancer Research.

Authors:  Paweł Sobczuk; Anna Brodziak; Mohammed Imran Khan; Stuti Chhabra; Michał Fiedorowicz; Marlena Wełniak-Kamińska; Kamil Synoradzki; Ewa Bartnik; Agnieszka Cudnoch-Jędrzejewska; Anna M Czarnecka
Journal:  Transl Oncol       Date:  2020-02-22       Impact factor: 4.243

7.  Renal carcinogenesis in the Eker rat.

Authors:  O Hino; E Kobayashi; M Nishizawa; Y Kubo; T Kobayashi; Y Hirayama; S Takai; Y Kikuchi; H Tsuchiya; K Orimoto
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

8.  cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.

Authors:  T Kobayashi; M Nishizawa; Y Hirayama; E Kobayashi; O Hino
Journal:  Nucleic Acids Res       Date:  1995-07-25       Impact factor: 16.971

Review 9.  Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.

Authors:  J Julie Kim; Takeshi Kurita; Serdar E Bulun
Journal:  Endocr Rev       Date:  2013-01-09       Impact factor: 19.871

Review 10.  Current Approaches and Future Directions for the Treatment of mTORopathies.

Authors:  Vasiliki Karalis; Helen S Bateup
Journal:  Dev Neurosci       Date:  2021-04-28       Impact factor: 2.984
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