Literature DB >> 11092843

Genetic models of obesity and energy balance in the mouse.

S W Robinson1, D M Dinulescu, R D Cone.   

Abstract

Obesity is a health problem of epidemic proportions in the industrialized world. The cloning and characterization of the genes for the five naturally occurring monogenic obesity syndromes in the mouse have led to major breakthroughs in understanding the physiology of energy balance and the contribution of genetics to obesity in the human population. However, the regulation of energy balance is an extremely complex process, and it is quickly becoming clear that hundreds of genes are involved. In this article, we review the naturally occurring monogenic and polygenic obese mouse strains, as well as the large number of transgenic and knockout mouse models currently available for the study of obesity and energy balance.

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Year:  2000        PMID： 11092843     DOI： 10.1146/annurev.genet.34.1.687

Source DB:  PubMed          Journal:  Annu Rev Genet        ISSN： 0066-4197            Impact factor:   16.830


  25 in total

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2.  Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice.

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Review 4.  Neuropeptide Y in normal eating and in genetic and dietary-induced obesity.

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Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-07-29       Impact factor: 6.237

5.  CYP1B1 deficiency ameliorates obesity and glucose intolerance induced by high fat diet in adult C57BL/6J mice.

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6.  Association between cholecystokinin type A receptor haplotypes and growth traits in Japanese Hinai-dori crossbred chickens.

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7.  Effect of gastric bypass combined with ileal transportation on type 2 diabetes mellitus.

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8.  An analysis of licking microstructure in three strains of mice.

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9.  Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis.

Authors:  Louise Strandberg; Margareta Verdrengh; Maria Enge; Niklas Andersson; Sylvie Amu; Karin Onnheim; Anna Benrick; Mikael Brisslert; Johan Bylund; Maria Bokarewa; Staffan Nilsson; John-Olov Jansson
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10.  Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Authors:  Linda C Enns; John F Morton; Ruby Sue Mangalindan; G Stanley McKnight; Michael W Schwartz; Matt R Kaeberlein; Brian K Kennedy; Peter S Rabinovitch; Warren C Ladiges
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-09-23       Impact factor: 6.053
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