Literature DB >> 10514374

Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses.

J Uchida1, T Yasui, Y Takaoka-Shichijo, M Muraoka, W Kulwichit, N Raab-Traub, H Kikutani.   

Abstract

The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.

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Year:  1999        PMID： 10514374     DOI： 10.1126/science.286.5438.300

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  146 in total

1.  Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1).

Authors:  K D Brown; B S Hostager; G A Bishop
Journal:  J Exp Med       Date:  2001-04-16       Impact factor: 14.307

2.  Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors.

Authors:  H Chen; J M Lee; Y Zong; M Borowitz; M H Ng; R F Ambinder; S D Hayward
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

3.  RelB nuclear translocation mediated by C-terminal activator regions of Epstein-Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells.

Authors:  Saparna Pai; Brendan J O'Sullivan; Leanne Cooper; Ranjeny Thomas; Rajiv Khanna
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

4.  Short-circuiting long-lived humoral immunity by the heightened engagement of CD40.

Authors:  Loren D Erickson; Brigit G Durell; Laura A Vogel; Brian P O'Connor; Marilia Cascalho; Teruhito Yasui; Hitoshi Kikutani; Randolph J Noelle
Journal:  J Clin Invest       Date:  2002-03       Impact factor: 14.808

5.  Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes.

Authors:  Hajir Dadgostar; Brian Zarnegar; Alexander Hoffmann; Xiao-Feng Qin; Uyen Truong; Govinda Rao; David Baltimore; Genhong Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-05       Impact factor: 11.205

6.  Preferential localization of the Epstein-Barr virus (EBV) oncoprotein LMP-1 to nuclei in human T cells: implications for its role in the development of EBV genome-positive T-cell lymphomas.

Authors:  Jingwu Xu; Ali Ahmad; José Menezes
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

7.  Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells.

Authors:  R S Harris; D S Croom-Carter; A B Rickinson; M S Neuberger
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

8.  CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex.

Authors:  A Kaykas; K Worringer; B Sugden
Journal:  EMBO J       Date:  2001-06-01       Impact factor: 11.598

9.  LMP-1's transmembrane domains encode multiple functions required for LMP-1's efficient signaling.

Authors:  Ajamete Kaykas; Kathleen Worringer; Bill Sugden
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

10.  The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity.

Authors:  J K Choi; S Ishido; J U Jung
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103
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