| Literature DB >> 11090360 |
F Lori1, M G Lewis, J Xu, G Varga, D E Zinn, C Crabbs, W Wagner, J Greenhouse, P Silvera, J Yalley-Ogunro, C Tinelli, J Lisziewicz.
Abstract
In a randomized controlled trial with acute simian immunodeficiency virus (SIV)-infected macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule structured treatment interruption (STI-HAART; alternating 3 weeks on and 3 weeks off therapy) suppressed viral load. In the STI-HAART group, T cell virus-specific immune response (VIR) and control of viral rebound increased concurrently during subsequent interruptions. In contrast, VIR did not increase and SIV rebounded after permanent treatment withdrawal in all animals on continuous HAART. Fixed-schedule STI-HAART appears to be an effective alternative to continuous HAART for the early treatment of retroviral infection.Entities:
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Year: 2000 PMID： 11090360 DOI： 10.1126/science.290.5496.1591
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728