Literature DB >> 19098497

Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.

Hendrik Streeck1, Heiko Jessen, Claudia Kuecherer, Bin Li, Arne B Jessen, Stephan Dupke, Axel Baumgarten, Ingrid Stahmer, Jan van Lunzen, Marcus Altfeld, Bruce D Walker, Todd M Allen.   

Abstract

The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.

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Year:  2009        PMID： 19098497      PMCID： PMC3082841          DOI： 10.1097/QAD.0b013e328315a78b

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  25 in total

1.  Control of HIV despite the discontinuation of antiretroviral therapy.

Authors:  J Lisziewicz; E Rosenberg; J Lieberman; H Jessen; L Lopalco; R Siliciano; B Walker; F Lori
Journal:  N Engl J Med       Date:  1999-05-27       Impact factor: 91.245

2.  Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection.

Authors:  Hendrik Streeck; Heiko Jessen; Galit Alter; Nickolas Teigen; Mike T Waring; Arne Jessen; Ingrid Stahmer; Jan van Lunzen; Mathias Lichterfeld; Xiaojiang Gao; Todd M Allen; Mary Carrington; Bruce D Walker; Juergen K Rockstroh; Marcus Altfeld
Journal:  J Infect Dis       Date:  2006-08-15       Impact factor: 5.226

3.  A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection.

Authors:  Frederick M Hecht; Lei Wang; Ann Collier; Susan Little; Martin Markowitz; Joseph Margolick; J Michael Kilby; Eric Daar; Brian Conway; Sarah Holte
Journal:  J Infect Dis       Date:  2006-08-15       Impact factor: 5.226

Review 4.  Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease.

Authors:  E A Berger; P M Murphy; J M Farber
Journal:  Annu Rev Immunol       Date:  1999       Impact factor: 28.527

5.  Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection.

Authors:  D A Price; P J Goulder; P Klenerman; A K Sewell; P J Easterbrook; M Troop; C R Bangham; R E Phillips
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

6.  HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.

Authors:  Margaret E Feeney; Yanhua Tang; Katja Pfafferott; Kathleen A Roosevelt; Rika Draenert; Alicja Trocha; Xu G Yu; Cori Verrill; Todd Allen; Corey Moore; Simon Mallal; Sandra Burchett; Kenneth McIntosh; Stephen I Pelton; M Anne St John; Rohan Hazra; Paul Klenerman; Marcus Altfeld; Bruce D Walker; Philip J R Goulder
Journal:  J Immunol       Date:  2005-06-15       Impact factor: 5.422

7.  Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection.

Authors:  Sabine Kinloch-de Loes; Bruno Hoen; Don E Smith; Brigitte Autran; Fiona C Lampe; Andrew N Phillips; Li-Ean Goh; Jan Andersson; Christos Tsoukas; Anders Sonnerborg; Giuseppe Tambussi; Pierre-Marie Girard; Mark Bloch; Manuel Battegay; Nick Carter; Raphaelle El Habib; Georgia Theofan; David A Cooper; Luc Perrin
Journal:  J Infect Dis       Date:  2005-07-15       Impact factor: 5.226

8.  A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.

Authors:  L G Kostrikis; Y Huang; J P Moore; S M Wolinsky; L Zhang; Y Guo; L Deutsch; J Phair; A U Neumann; D D Ho
Journal:  Nat Med       Date:  1998-03       Impact factor: 53.440

9.  Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.

Authors:  R A Kaslow; M Carrington; R Apple; L Park; A Muñoz; A J Saah; J J Goedert; C Winkler; S J O'Brien; C Rinaldo; R Detels; W Blattner; J Phair; H Erlich; D L Mann
Journal:  Nat Med       Date:  1996-04       Impact factor: 53.440

10.  Limited durability of viral control following treated acute HIV infection.

Authors:  Daniel E Kaufmann; Mathias Lichterfeld; Marcus Altfeld; Marylyn M Addo; Mary N Johnston; Paul K Lee; Bradford S Wagner; Elizabeth T Kalife; Daryld Strick; Eric S Rosenberg; Bruce D Walker
Journal:  PLoS Med       Date:  2004-10-26       Impact factor: 11.069
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  2 in total

1.  Second European Round Table on the Future Management of HIV: 10-11 October 2014, Barcelona, Spain.

Authors:  Casper Rokx; Douglas D Richman; Michaela Müller-Trutwin; Guido Silvestri; Jan Lunzen; Saye Khoo; Mathias Lichterfeld; Marcus Altfeld; Carlo Federico Perno; Peter W Hunt; Paddy Mallon; Jürgen K Rockstroh; Anton L Pozniak; Bonaventura Clotet; Charles Ab Boucher
Journal:  J Virus Erad       Date:  2015-07-01

2.  Immune Correlates of Disease Progression in Linked HIV-1 Infection.

Authors:  Michael Tuen; Jude S Bimela; Andrew N Banin; Shilei Ding; Gordon W Harkins; Svenja Weiss; Vincenza Itri; Allison R Durham; Stephen F Porcella; Sonal Soni; Luzia Mayr; Josephine Meli; Judith N Torimiro; Marcel Tongo; Xiaohong Wang; Xiang-Peng Kong; Arthur Nádas; Daniel E Kaufmann; Zabrina L Brumme; Aubin J Nanfack; Thomas C Quinn; Susan Zolla-Pazner; Andrew D Redd; Andrés Finzi; Miroslaw K Gorny; Phillipe N Nyambi; Ralf Duerr
Journal:  Front Immunol       Date:  2019-05-14       Impact factor: 7.561
  2 in total

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