| Literature DB >> 11090273 |
R B Langkjaer1, M L Nielsen, P R Daugaard, W Liu, J Piskur.
Abstract
The structure of the first eukaryotic genome, belonging to Saccharomyces cerevisiae, has been deduced; however, very little is known about its origin. In order to trace events that led to the current state of the Saccharomyces nuclear genomes, random fragments of genomic DNA from three yeasts were sequenced and compared to the S. cerevisiae database sequence. Whereas, S. cerevisiae and Saccharomyces bayanus show perfect synteny, a significant portion of the analysed fragments from Saccharomyces servazzii and Saccharomyces kluyveri show a different arrangement of genes when compared to S. cerevisiae. When the sequenced fragments were probed to the corresponding karyotype, a group of genes present on a single chromosome of S. servazzii and S. kluyveri had homologues scattered on several S. cerevisiae chromosomes. Apparently, extensive reorganisation of the chromosomes has taken place during evolution of the Saccharomyces yeasts. In addition, while one gross duplication could have taken place, at least a few genes have been duplicated independently at different time-points in the evolution. Copyright 2000 Academic Press.Entities:
Mesh：
Substances：
Year: 2000 PMID： 11090273 DOI： 10.1006/jmbi.2000.4209
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469