| Literature DB >> 11087590 |
Y Hathout1, Y P Ho, V Ryzhov, P Demirev, C Fenselau.
Abstract
A novel class of lipopeptides was isolated from Bacillus thuringiensis kurstaki HD-1. Four compounds (1-4) were separated by high-performance liquid chromatography and their primary structures determined using a combination of chemical reactions and mass spectrometry. The four lipopeptides were found to have the same amino acid sequence, Thr-Gly-Ala-Ser-His-Gln-Gln, but different fatty acids. The fatty acyl chain is linked to the N-terminal amino acid residue via an amide bond. Each lipopeptide has a lactone linkage between the carboxyl terminal amino acid and the hydroxyl group in the side chain of the serine residue. Antifungal activity was demonstrated against Stachybotrys charatum.Entities:
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Year: 2000 PMID： 11087590 DOI： 10.1021/np000169q
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050