Literature DB >> 11087586

Cytotoxic constituents of Polyalthia longifolia var. pendula.

C Y Chen1, F R Chang, Y C Shih, T J Hsieh, Y C Chia, H Y Tseng, H C Chen, S J Chen, M C Hsu, Y C Wu.   

Abstract

A new halimane diterpene, 3beta,5beta, 16alpha-trihydroxyhalima-13(14)-en-15,16-olide (1), and a new oxoprotoberberine alkaloid, (-)-8-oxopolyalthiaine (2), along with 20 known compounds, were isolated from a methanolic extract of Polyalthia longifolia var. pendula. The structures of compounds 1 and 2 were established by spectroscopic analysis. Several of these compounds were evaluated for cytotoxicity toward a small panel of human cell lines.

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Year:  2000        PMID： 11087586     DOI： 10.1021/np000176e

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

1.  The medicinal plants of Myanmar.

Authors:  Robert A DeFilipps; Gary A Krupnick
Journal:  PhytoKeys       Date:  2018-06-28       Impact factor: 1.635

2.  Green biocide for mitigating sulfate-reducing bacteria influenced microbial corrosion.

Authors:  Shanthi Vaithiyanathan; Karthikeyan Chandrasekaran; R C Barik
Journal:  3 Biotech       Date:  2018-11-21       Impact factor: 2.406

3.  16alpha-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: a safe and orally active antileishmanial agent.

Authors:  Pragya Misra; Koneni V Sashidhara; Suriya Pratap Singh; Awanish Kumar; Reema Gupta; Shailendra S Chaudhaery; Souvik Sen Gupta; H K Majumder; Anil K Saxena; Anuradha Dube
Journal:  Br J Pharmacol       Date:  2010-02-05       Impact factor: 8.739

4.  A novel, semi-synthetic diterpenoid 16(R and S)-phenylamino-cleroda-3,13(14), Z-dien-15,16 olide (PGEA-AN) inhibits the growth and cell survival of human neuroblastoma cell line SH-SY5Y by modulating P53 pathway.

Authors:  Syed Saad Hussain; Kinza Rafi; Shaheen Faizi; Zaid Abdul Razzak; Shabana U Simjee
Journal:  Mol Cell Biochem       Date:  2018-04-11       Impact factor: 3.396

5.  The chemistry, pharmacologic, and therapeutic applications of Polyalthia longifolia.

Authors:  K V Katkar; A C Suthar; V S Chauhan
Journal:  Pharmacogn Rev       Date:  2010-01

6.  Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria.

Authors:  A E Bankole; A A Adekunle; A A Sowemimo; C E Umebese; O Abiodun; G O Gbotosho
Journal:  Parasitol Res       Date:  2015-09-22       Impact factor: 2.289

7.  Encapsulation of 16-Hydroxycleroda-3,13-Dine-16,15-Olide in Mesoporous Silica Nanoparticles as a Natural Dipeptidyl Peptidase-4 Inhibitor Potentiated Hypoglycemia in Diabetic Mice.

Authors:  Po-Kai Huang; Shi-Xiang Lin; May-Jywan Tsai; Max K Leong; Shian-Ren Lin; Ranjith Kumar Kankala; Chia-Hung Lee; Ching-Feng Weng
Journal:  Nanomaterials (Basel)       Date:  2017-05-12       Impact factor: 5.076

8.  16-Hydroxycleroda-3,13-dien-15,16-olide induces anoikis in human renal cell carcinoma cells: involvement of focal adhesion disassembly and signaling.

Authors:  Yu-Chi Chen; Bu-Miin Huang; Wei-Chang Lee; Yung-Chia Chen
Journal:  Onco Targets Ther       Date:  2018-10-31       Impact factor: 4.147

9.  Clerodane Diterpene Ameliorates Inflammatory Bowel Disease and Potentiates Cell Apoptosis of Colorectal Cancer.

Authors:  Jia-Huei Zheng; Shian-Ren Lin; Feng-Jen Tseng; May-Jywan Tsai; Sheng-I Lue; Yi-Chen Chia; Mindar Woon; Yaw-Syan Fu; Ching-Feng Weng
Journal:  Biomolecules       Date:  2019-11-21

10.  16-Hydroxycleroda-3,13-dien-15,16-olide and N-Methyl-Actinodaphine Potentiate Tamoxifen-Induced Cell Death in Breast Cancer.

Authors:  Bharath Kumar Velmurugan; Po-Chih Wang; Ching-Feng Weng
Journal:  Molecules       Date:  2018-08-06       Impact factor: 4.411
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