| Literature DB >> 11086729 |
H F Boyd1, S C Fell, S T Flynn, D M Hickey, R J Ife, C A Leach, C H Macphee, K J Milliner, K E Moores, I L Pinto, R A Porter, D A Rawlings, S A Smith, I G Stansfield, D G Tew, C J Theobald, C M Whittaker.
Abstract
From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human lipoprotein-associated phospholipase A2. These compounds show greatly enhanced activity in isolated plasma. Selected derivatives such as compounds 51 and 52 are orally active with a good duration of action.Entities:
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Year: 2000 PMID： 11086729 DOI： 10.1016/s0960-894x(00)00510-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823