BACKGROUND: Anorexia nervosa is highly prevalent among young women. OBJECTIVE: To determine prevalence and predictive factors for regional bone loss. DESIGN: Prospective cohort analysis. SETTING: University hospital. PATIENTS: 130 women with anorexia nervosa. MEASUREMENTS: Dual-energy x-ray absorptiometry. RESULTS: The prevalence of osteopenia (-1.0 SD >/= T-score > -2.5 SD) and osteoporosis (T-score </= -2.5 SD) was 50% and 13% for the anterior-posterior spine, 57% and 24% for the lateral spine, and 47% and 16% for the total hip, respectively. Bone mineral density (BMD) was reduced by at least 1.0 SD at one or more skeletal sites in 92% of patients and by at least 2.5 SD in 38% of patients. Weight was the most consistent predictor of BMD at all skeletal sites. Twenty-three percent of patients were current estrogen users, and 58% were previous estrogen users. Bone mineral density did not differ by history of estrogen use at any site. CONCLUSIONS: Bone mineral density is reduced at several skeletal sites in most women with anorexia nervosa. Weight, but not estrogen use, is a significant predictor of BMD in this population at all skeletal sites.
BACKGROUND:Anorexia nervosa is highly prevalent among young women. OBJECTIVE: To determine prevalence and predictive factors for regional bone loss. DESIGN: Prospective cohort analysis. SETTING: University hospital. PATIENTS: 130 women with anorexia nervosa. MEASUREMENTS: Dual-energy x-ray absorptiometry. RESULTS: The prevalence of osteopenia (-1.0 SD >/= T-score > -2.5 SD) and osteoporosis (T-score </= -2.5 SD) was 50% and 13% for the anterior-posterior spine, 57% and 24% for the lateral spine, and 47% and 16% for the total hip, respectively. Bone mineral density (BMD) was reduced by at least 1.0 SD at one or more skeletal sites in 92% of patients and by at least 2.5 SD in 38% of patients. Weight was the most consistent predictor of BMD at all skeletal sites. Twenty-three percent of patients were current estrogen users, and 58% were previous estrogen users. Bone mineral density did not differ by history of estrogen use at any site. CONCLUSIONS: Bone mineral density is reduced at several skeletal sites in most women with anorexia nervosa. Weight, but not estrogen use, is a significant predictor of BMD in this population at all skeletal sites.
Authors: W Herzog; H Minne; C Deter; G Leidig; D Schellberg; C Wüster; R Gronwald; E Sarembe; F Kröger; G Bergmann Journal: J Bone Miner Res Date: 1993-05 Impact factor: 6.741
Authors: S Grinspoon; K Miller; C Coyle; J Krempin; C Armstrong; S Pitts; D Herzog; A Klibanski Journal: J Clin Endocrinol Metab Date: 1999-06 Impact factor: 5.958
Authors: S R Cummings; D M Black; M C Nevitt; W Browner; J Cauley; K Ensrud; H K Genant; L Palermo; J Scott; T M Vogt Journal: Lancet Date: 1993-01-09 Impact factor: 79.321
Authors: J S Finkelstein; R L Cleary; J P Butler; R Antonelli; B H Mitlak; D J Deraska; J C Zamora-Quezada; R M Neer Journal: J Clin Endocrinol Metab Date: 1994-03 Impact factor: 5.958
Authors: Melanie Schorr; Jennifer J Thomas; Kamryn T Eddy; Laura E Dichtel; Elizabeth A Lawson; Erinne Meenaghan; Margaret Lederfine Paskal; Pouneh K Fazeli; Alexander T Faje; Madhusmita Misra; Anne Klibanski; Karen K Miller Journal: Int J Eat Disord Date: 2016-08-16 Impact factor: 4.861