Literature DB >> 11083843

Human CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia.

S M Smith1, M R Klein, A S Malin, J Sillah, K Huygen, P Andersen, K P McAdam, H M Dockrell.   

Abstract

Intracellular flow cytometry analysis of perforin production by CD8(+) T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8(+) T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients.

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Year:  2000        PMID： 11083843      PMCID： PMC97828          DOI： 10.1128/IAI.68.12.7144-7148.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

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Journal:  J Immunol       Date:  1999-01-01       Impact factor: 5.422

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Journal:  J Immunol       Date:  1995-04-01       Impact factor: 5.422

6.  Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis.

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Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

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Authors:  I M Orme; P Andersen; W H Boom
Journal:  J Infect Dis       Date:  1993-06       Impact factor: 5.226

10.  Characterization of human Mycobacterium bovis bacille Calmette-Guérin-reactive CD8+ T cells.

Authors:  S M Smith; A S Malin; T Pauline; S E Atkinson; J Content; K Huygen; H M Dockrell
Journal:  Infect Immun       Date:  1999-10       Impact factor: 3.441
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  24 in total

1.  HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.

Authors:  Michèl R Klein; Abdulrahman S Hammond; Steve M Smith; Assan Jaye; Pauline T Lukey; Keith P W J McAdam
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

2.  Decreased expression of perforin in CD8+ T lymphocytes in patients with Mycobacterium tuberculosis infection and its potential value as a marker for efficacy of treatment.

Authors:  Hongbin Jiang; Huili Gong; Qing Zhang; Jin Gu; Li Liang; Jun Zhang
Journal:  J Thorac Dis       Date:  2017-05       Impact factor: 2.895

Review 3.  Antigens for CD4 and CD8 T cells in tuberculosis.

Authors:  Cecilia S Lindestam Arlehamn; David Lewinsohn; Alessandro Sette; Deborah Lewinsohn
Journal:  Cold Spring Harb Perspect Med       Date:  2014-05-22       Impact factor: 6.915

4.  Pleural mesothelial cells promote expansion of IL-17-producing CD8+ T cells in tuberculous pleural effusion.

Authors:  X Li; Q Zhou; W B Yang; X Z Xiong; R H Du; J C Zhang
Journal:  J Clin Immunol       Date:  2013-01-09       Impact factor: 8.317

5.  Mycobacterium tuberculosis growth control by lung macrophages and CD8 cells from patient contacts.

Authors:  Claudia Carranza; Esmeralda Juárez; Martha Torres; Jerrold J Ellner; Eduardo Sada; Stephan K Schwander
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6.  T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients.

Authors:  Fernando L L Cardoso; Paulo R Z Antas; Alexandre S Milagres; Annemieke Geluk; Kees L M C Franken; Eliane B Oliveira; Henrique C Teixeira; Susie A Nogueira; Euzenir N Sarno; Paul Klatser; Tom H M Ottenhoff; Elizabeth P Sampaio
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

7.  Evaluation of T-cell responses to novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection.

Authors:  Xiao-Qing Liu; Davinder Dosanjh; Hansa Varia; Katie Ewer; Paul Cockle; Geoffrey Pasvol; Ajit Lalvani
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441

8.  Specific lytic activity against mycobacterial antigens is inversely correlated with the severity of tuberculosis.

Authors:  S S De La Barrera; M Finiasz; A Frias; M Alemán; P Barrionuevo; S Fink; M C Franco; E Abbate; M del C Sasiain
Journal:  Clin Exp Immunol       Date:  2003-06       Impact factor: 4.330

9.  Immunologic analysis of HIV-uninfected Taiwanese children with BCG-induced disease.

Authors:  Wen-I Lee; Fang-Chen Liang; Jing-Long Huang; Tang-Her Jaing; Chi-Huei Wang; Tzou-Yien Lin; Yhu-Chering Huang; Wei-Lun Huang; Ruwen Jou; Meng-Ying Hsieh; Ju-Hsin Chia; Tsu-Lan Wu
Journal:  J Clin Immunol       Date:  2008-12-13       Impact factor: 8.317

10.  The Mycobacterium tuberculosis complex-restricted gene cfp32 encodes an expressed protein that is detectable in tuberculosis patients and is positively correlated with pulmonary interleukin-10.

Authors:  Richard C Huard; Sadhana Chitale; Mary Leung; Luiz Claudio Oliveira Lazzarini; Hongxia Zhu; Elena Shashkina; Suman Laal; Marcus B Conde; Afrânio L Kritski; John T Belisle; Barry N Kreiswirth; José Roberto Lapa e Silva; John L Ho
Journal:  Infect Immun       Date:  2003-12       Impact factor: 3.441
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