| Literature DB >> 11796635 |
Michèl R Klein1, Abdulrahman S Hammond, Steve M Smith, Assan Jaye, Pauline T Lukey, Keith P W J McAdam.
Abstract
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha.Entities:
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Year: 2002 PMID: 11796635 PMCID: PMC127663 DOI: 10.1128/IAI.70.2.981-984.2002
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441