Literature DB >> 11796635

HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.

Michèl R Klein1, Abdulrahman S Hammond, Steve M Smith, Assan Jaye, Pauline T Lukey, Keith P W J McAdam.   

Abstract

Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha.

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Year:  2002        PMID: 11796635      PMCID: PMC127663          DOI: 10.1128/IAI.70.2.981-984.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  21 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

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Journal:  Infect Immun       Date:  1999-10       Impact factor: 3.441

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  6 in total

1.  Mycobacterium tuberculosis genome-wide screen exposes multiple CD8 T cell epitopes.

Authors:  A S Hammond; M R Klein; T Corrah; A Fox; A Jaye; K P McAdam; R H Brookes
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3.  Identification of CD8 T-lymphocyte epitopes in OmpB of Rickettsia conorii.

Authors:  Zhen Li; C Marcela Díaz-Montero; Gustavo Valbuena; Xue-Jie Yu; Juan P Olano; Hui-Min Feng; David H Walker
Journal:  Infect Immun       Date:  2003-07       Impact factor: 3.441

4.  Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection.

Authors:  Nadia Caccamo; Giuliana Guggino; Serena Meraviglia; Giuseppe Gelsomino; Paola Di Carlo; Lucina Titone; Marialuisa Bocchino; Domenico Galati; Alessandro Matarese; Jan Nouta; Michel R Klein; Alfredo Salerno; Alessandro Sanduzzi; Francesco Dieli; Tom H M Ottenhoff
Journal:  PLoS One       Date:  2009-05-13       Impact factor: 3.240

5.  Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B.

Authors:  Deborah A Lewinsohn; Ervina Winata; Gwendolyn M Swarbrick; Katie E Tanner; Matthew S Cook; Megan D Null; Meghan E Cansler; Alessandro Sette; John Sidney; David M Lewinsohn
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6.  Human CD8+ T cells from TB pleurisy respond to four immunodominant epitopes in Mtb CFP10 restricted by HLA-B alleles.

Authors:  Li Li; Binyan Yang; Sifei Yu; Xianlan Zhang; Suihua Lao; Changyou Wu
Journal:  PLoS One       Date:  2013-12-12       Impact factor: 3.240

  6 in total

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