OBJECTIVES: To review, on a genome-wide scale, a linkage result obtained in an earlier candidate gene analysis in this same study sample, and to look for other possible contributing genetic loci predisposing to hypertension in this population. DESIGN: An affected sibpair linkage study with highly polymorphic genetic markers spanning the genome at an average intermarker density of 10 cM. PARTICIPANTS: A total of 47 families with two affected siblings (mostly dizygotic twins) and all available additional family members from the genetic isolate of Finland. The families were identified through the Finnish Twin Cohort Study, the total number of this follow-up cohort being 13,888. The study sample was selected on the basis of early-onset hypertension with minimal presence of other phenotypic risk factors such as obesity. RESULTS: The AT1 locus stood out as the most significant locus in this population (maximum likelihood score 4.04). Some evidence for linkage was also detected with markers on chromosomes 2q (maximum likelihood score 2.96), 22q (2.07), and Xp (2.41). CONCLUSIONS: Our results establish the role of the AT1 locus, on a genome-wide scale, as a major contributing locus to essential hypertension in this study sample.
OBJECTIVES: To review, on a genome-wide scale, a linkage result obtained in an earlier candidate gene analysis in this same study sample, and to look for other possible contributing genetic loci predisposing to hypertension in this population. DESIGN: An affected sibpair linkage study with highly polymorphic genetic markers spanning the genome at an average intermarker density of 10 cM. PARTICIPANTS: A total of 47 families with two affected siblings (mostly dizygotic twins) and all available additional family members from the genetic isolate of Finland. The families were identified through the Finnish Twin Cohort Study, the total number of this follow-up cohort being 13,888. The study sample was selected on the basis of early-onset hypertension with minimal presence of other phenotypic risk factors such as obesity. RESULTS: The AT1 locus stood out as the most significant locus in this population (maximum likelihood score 4.04). Some evidence for linkage was also detected with markers on chromosomes 2q (maximum likelihood score 2.96), 22q (2.07), and Xp (2.41). CONCLUSIONS: Our results establish the role of the AT1 locus, on a genome-wide scale, as a major contributing locus to essential hypertension in this study sample.
Authors: M Perola; M Ohman; T Hiekkalinna; J Leppävuori; P Pajukanta; M Wessman; M Koskenvuo; A Palotie; K Lange; J Kaprio; L Peltonen Journal: Am J Hum Genet Date: 2001-06-15 Impact factor: 11.025
Authors: K Gopalakrishnan; J Saikumar; C G Peters; S Kumarasamy; P Farms; S Yerga-Woolwine; E J Toland; W Schnackel; D R Giovannucci; B Joe Journal: Physiol Genomics Date: 2010-08-17 Impact factor: 3.107
Authors: Tanika N Kelly; James E Hixson; Dabeeru C Rao; Hao Mei; Treva K Rice; Cashell E Jaquish; Lawrence C Shimmin; Karen Schwander; Chung-Shuian Chen; Depei Liu; Jichun Chen; Concetta Bormans; Pramila Shukla; Naveed Farhana; Colin Stuart; Paul K Whelton; Jiang He; Dongfeng Gu Journal: Circ Cardiovasc Genet Date: 2010-09-22
Authors: P Hamet; E Merlo; O Seda; U Broeckel; J Tremblay; M Kaldunski; D Gaudet; G Bouchard; B Deslauriers; F Gagnon; G Antoniol; Z Pausová; M Labuda; M Jomphe; F Gossard; G Tremblay; R Kirova; P Tonellato; S N Orlov; J Pintos; J Platko; T J Hudson; J D Rioux; T A Kotchen; A W Cowley Journal: Am J Hum Genet Date: 2005-03-30 Impact factor: 11.025
Authors: Heming Wang; Priyanka Nandakumar; Fasil Tekola-Ayele; Bamidele O Tayo; Erin B Ware; C Charles Gu; Yingchang Lu; Jie Yao; Wei Zhao; Jennifer A Smith; Jacklyn N Hellwege; Xiuqing Guo; Todd L Edwards; Ruth J F Loos; Donna K Arnett; Myriam Fornage; Charles Rotimi; Sharon L R Kardia; Richard S Cooper; D C Rao; Georg Ehret; Aravinda Chakravarti; Xiaofeng Zhu Journal: Eur J Hum Genet Date: 2018-09-27 Impact factor: 4.246
Authors: Andrea Angius; Enrico Petretto; Giovanni Battista Maestrale; Paola Forabosco; Giuseppina Casu; Daniela Piras; Manuela Fanciulli; Mario Falchi; Paola Maria Melis; Mario Palermo; Mario Pirastu Journal: Am J Hum Genet Date: 2002-09-12 Impact factor: 11.025