Literature DB >> 11079799

Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities.

J Schimana1, H P Fiedler, I Groth, R Süssmuth, W Beil, M Walker, A Zeeck.   

Abstract

Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.

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Year:  2000        PMID： 11079799     DOI： 10.7164/antibiotics.53.779

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  25 in total

1.  Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.

Authors:  A Trefzer; S Pelzer; J Schimana; S Stockert; C Bihlmaier; H-P Fiedler; K Welzel; A Vente; A Bechthold
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

2.  Coumarin-benzimidazole hybrids as a potent antimicrobial agent: synthesis and biological elevation.

Authors:  L Ravithej Singh; Srinivasa Rao Avula; Sneha Raj; Akanksha Srivastava; Gopala Reddy Palnati; C K M Tripathi; Mukesh Pasupuleti; Koneni V Sashidhara
Journal:  J Antibiot (Tokyo)       Date:  2017-06-21       Impact factor: 2.649

Review 3.  Astonishing diversity of natural surfactants: 4. Fatty acid amide glycosides, their analogs and derivatives.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2005-07       Impact factor: 1.880

Review 4.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

Review 5.  Topoisomerases as anticancer targets.

Authors:  Justine L Delgado; Chao-Ming Hsieh; Nei-Li Chan; Hiroshi Hiasa
Journal:  Biochem J       Date:  2018-01-23       Impact factor: 3.857

6.  Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002.

Authors:  Mohamed S Abdelfattah; Madan Kumar Kharel; John Andrew Hitron; Irfan Baig; Jürgen Rohr
Journal:  J Nat Prod       Date:  2008-07-31       Impact factor: 4.050

7.  In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.

Authors:  Lisa M Oppegard; Bree L Hamann; Kathryn R Streck; Keith C Ellis; Hans-Peter Fiedler; Arkady B Khodursky; Hiroshi Hiasa
Journal:  Antimicrob Agents Chemother       Date:  2009-03-09       Impact factor: 5.191

8.  Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II.

Authors:  Ahad A Sadiq; Manish R Patel; Blake A Jacobson; Marco Escobedo; Keith Ellis; Lisa M Oppegard; Hiroshi Hiasa; Robert A Kratzke
Journal:  Invest New Drugs       Date:  2009-01-10       Impact factor: 3.850

9.  Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.

Authors:  C Sissi; E Vazquez; A Chemello; L A Mitchenall; A Maxwell; M Palumbo
Journal:  Antimicrob Agents Chemother       Date:  2009-10-26       Impact factor: 5.191

10.  Protective effect of Qnr on agents other than quinolones that target DNA gyrase.

Authors:  George A Jacoby; Marian A Corcoran; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191
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