Literature DB >> 11067584

Genetic research as therapy: implications of "gene therapy" for informed consent.

L R Churchill1, M L Collins, N M King, S G Pemberton, K A Wailoo.   

Abstract

Authors argue that characterization of gene transfer research as "gene therapy" has compromised informed consent in the current environment of regulatory exceptions, routinized consent, fostered therapeutic misconceptions, and oversold research.

Keywords:  Belmont Report; Biomedical and Behavioral Research; Genetics and Reproduction; Human Genome Project; Legal Approach; Recombinant DNA Advisory Committee

Mesh：

Year:  1998        PMID： 11067584     DOI： 10.1111/j.1748-720x.1998.tb01904.x

Source DB:  PubMed          Journal:  J Law Med Ethics        ISSN： 1073-1105            Impact factor:   1.718


  7 in total

1.  Protection at the cutting edge: the case for central review of human gene transfer research.

Authors:  Jonathan Kimmelman
Journal:  CMAJ       Date:  2003-10-14       Impact factor: 8.262

2.  Genetics and bioethics: how our thinking has changed since 1969.

Authors:  LeRoy Walters
Journal:  Theor Med Bioeth       Date:  2012-02

3.  Therapeutic optimism in the consent forms of phase 1 gene transfer trials: an empirical analysis.

Authors:  J Kimmelman; N Palmour
Journal:  J Med Ethics       Date:  2005-04       Impact factor: 2.903

4.  A survey of genetic counselors' use of informed consent documents for prenatal genetic counseling sessions.

Authors:  G M Jacobson; P M Veach; B S LeRoy
Journal:  J Genet Couns       Date:  2001-02       Impact factor: 2.537

Review 5.  Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?

Authors:  Claire T Deakin; Ian E Alexander; Ian Kerridge
Journal:  Mol Ther       Date:  2009-09-22       Impact factor: 11.454

6.  Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception.

Authors:  Yan Leykin; Paul P Christopher; Paul E Holtzheimer; Paul S Appelbaum; Helen S Mayberg; Sarah H Lisanby; Laura B Dunn
Journal:  AJOB Prim Res       Date:  2011-10

7.  The ethics of withdrawal from study participation.

Authors:  Elisa J Gordon; Thomas R Prohaska
Journal:  Account Res       Date:  2006 Oct-Dec       Impact factor: 3.057
  7 in total

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