Literature DB >> 11060540

Protein C deficiency related to valproic acid therapy: a possible association with childhood stroke.

R Gruppo1, A Degrauw, H Fogelson, T Glauser, V Balasa, P Gartside.   

Abstract

We report a case of stroke in a child with acquired protein C deficiency receiving valproic acid (VPA). To investigate the possible association of VPA with protein C deficiency, protein C levels were measured in 20 children receiving VPA monotherapy and 20 children receiving other anticonvulsants. Protein C levels were reduced in up to 45% of the VPA-treated subjects.

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Year:  2000        PMID： 11060540     DOI： 10.1067/mpd.2000.108565

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  4 in total

1.  Protein S gene mutation in a young woman with type III protein S deficiency and venous thrombosis during pregnancy.

Authors:  Masaya Hirose; Fuminori Kimura; Hua-Qin Wang; Koichi Takebayashi; Masashi Kobayashi; Keiko Nakanishi; Minoru Akiyama; Toshio Kimura; Yoichi Noda
Journal:  J Thromb Thrombolysis       Date:  2002-04       Impact factor: 2.300

2.  Pediatric stroke: a review.

Authors:  Daniel S Tsze; Jonathan H Valente
Journal:  Emerg Med Int       Date:  2011-12-27       Impact factor: 1.112

3.  Valproic acid influences the expression of genes implicated with hyperglycaemia-induced complement and coagulation pathways.

Authors:  Marina Barreto Felisbino; Mark Ziemann; Ishant Khurana; Jun Okabe; Keith Al-Hasani; Scott Maxwell; K N Harikrishnan; Camila Borges Martins de Oliveira; Maria Luiza S Mello; Assam El-Osta
Journal:  Sci Rep       Date:  2021-01-25       Impact factor: 4.379

4.  Ischemic Stroke in Confederation with Trivial Head Trauma.

Authors:  Archana Balachandran; Siddarameshwar Kalyanshettar; Shankargouda Patil; Vijaykumar Shegji
Journal:  Case Rep Pediatr       Date:  2016-05-29
  4 in total

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