Literature DB >> 11060110

Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?

M R Hammerschlag1, Z Ke, F Lu, P Roblin, J Boman, B Kalman.   

Abstract

We investigated the presence of Chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. All results were negative. Thus, this study on a large number of brain tissues suggests that C. pneumoniae is not involved in inflammatory demyelination.

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Year:  2000        PMID： 11060110      PMCID： PMC87583     

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  17 in total

1.  Failure to detect Chlamydia pneumoniae in brain tissues of Alzheimer's disease.

Authors:  D Nochlin; C M Shaw; L A Campbell; C C Kuo
Journal:  Neurology       Date:  1999-11-10       Impact factor: 9.910

2.  Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis.

Authors:  G Layh-Schmitt; C Bendl; U Hildt; T Dong-Si; E Jüttler; P Schnitzler; C Grond-Ginsbach; A J Grau
Journal:  Ann Neurol       Date:  2000-05       Impact factor: 10.422

3.  Analytical sensitivity, reproducibility of results, and clinical performance of five PCR assays for detecting Chlamydia pneumoniae DNA in peripheral blood mononuclear cells.

Authors:  J B Mahony; S Chong; B K Coombes; M Smieja; A Petrich
Journal:  J Clin Microbiol       Date:  2000-07       Impact factor: 5.948

4.  Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients.

Authors:  J Gieffers; E Reusche; W Solbach; M Maass
Journal:  J Clin Microbiol       Date:  2000-02       Impact factor: 5.948

5.  Multiple sclerosis and Chlamydia pneumoniae.

Authors:  J Treib; A Haass; W Stille; M Maass; C Stephan; G Holzer; M Morgenthaler; R Woessner; M T Grauer
Journal:  Ann Neurol       Date:  2000-03       Impact factor: 10.422

6.  Use of HEp-2 cells for improved isolation and passage of Chlamydia pneumoniae.

Authors:  P M Roblin; W Dumornay; M R Hammerschlag
Journal:  J Clin Microbiol       Date:  1992-08       Impact factor: 5.948

7.  Comparison of different methods for extraction of DNA of fungal pathogens from cultures and blood.

Authors:  J Löffler; H Hebart; U Schumacher; H Reitze; H Einsele
Journal:  J Clin Microbiol       Date:  1997-12       Impact factor: 5.948

8.  Failure to detect Chlamydia pneumoniae in the late-onset Alzheimer's brain.

Authors:  R H Ring; J M Lyons
Journal:  J Clin Microbiol       Date:  2000-07       Impact factor: 5.948

9.  Detection of Chlamydia pneumoniae and Chlamydia psittaci in sputum samples by PCR.

Authors:  C Y Tong; M Sillis
Journal:  J Clin Pathol       Date:  1993-04       Impact factor: 3.411

10.  Lower prevalence of Chlamydia pneumoniae DNA compared with Chlamydia trachomatis DNA in synovial tissue of arthritis patients.

Authors:  H R Schumacher; H C Gérard; T K Arayssi; J A Pando; P J Branigan; D L Saaibi; A P Hudson
Journal:  Arthritis Rheum       Date:  1999-09
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  9 in total

1.  Replicate PCR testing and probit analysis for detection and quantitation of Chlamydia pneumoniae in clinical specimens.

Authors:  M Smieja; J B Mahony; C H Goldsmith; S Chong; A Petrich; M Chernesky
Journal:  J Clin Microbiol       Date:  2001-05       Impact factor: 5.948

2.  Inclusion fluorescent-antibody test as a screening assay for detection of antibodies to Chlamydia pneumoniae.

Authors:  Olga Tapia; Anatoly Slepenkin; Evgueni Sevrioukov; Kathi Hamor; Luis M de la Maza; Ellena M Peterson
Journal:  Clin Diagn Lab Immunol       Date:  2002-05

3.  Real time PCR for detection of Chlamydophila pneumoniae in peripheral blood mononuclear cells of patients with multiple sclerosis.

Authors:  Rosa Sessa; Giovanna Schiavoni; Giovanna Borriello; Carlo Zagaglia; Fabiana Marinelli; Massimo del Piano; Carlo Pozzilli
Journal:  J Neurol       Date:  2007-04-26       Impact factor: 4.849

4.  Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders.

Authors:  Carlo Contini; Silva Seraceni; Rosario Cultrera; Massimiliano Castellazzi; Enrico Granieri; Enrico Fainardi
Journal:  Interdiscip Perspect Infect Dis       Date:  2010-02-21

5.  Development and evaluation of real-time PCR-based fluorescence assays for detection of Chlamydia pneumoniae.

Authors:  Maria Lucia C Tondella; Deborah F Talkington; Brian P Holloway; Scott F Dowell; Karyn Cowley; Montse Soriano-Gabarro; Mitchell S Elkind; Barry S Fields
Journal:  J Clin Microbiol       Date:  2002-02       Impact factor: 5.948

6.  Detection of Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis by combination of cell culture and PCR: no evidence for possible association.

Authors:  Stylianos Chatzipanagiotou; Constantinos Tsakanikas; Maria Anagnostouli; Michalis Rentzos; Anastassios Ioannidis; Chryssoula Nicolaou
Journal:  Mol Diagn       Date:  2003

Review 7.  Hit-Hit and hit-Run: viruses in the playing field of multiple sclerosis.

Authors:  I A Scarisbrick; M Rodriguez
Journal:  Curr Neurol Neurosci Rep       Date:  2003-05       Impact factor: 6.030

8.  Qualitative and quantitative detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid from multiple sclerosis patients and controls.

Authors:  Yi-Wei Tang; Subramaniam Sriram; Haijing Li; Song-yi Yao; Shufang Meng; William M Mitchell; Charles W Stratton
Journal:  PLoS One       Date:  2009-04-09       Impact factor: 3.240

Review 9.  Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or Pulmonary Chlamydia Infections.

Authors:  Yi Ying Cheok; Chalystha Yie Qin Lee; Heng Choon Cheong; Chung Yeng Looi; Won Fen Wong
Journal:  Microorganisms       Date:  2020-01-17
  9 in total

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