Literature DB >> 10655406

Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients.

J Gieffers1, E Reusche, W Solbach, M Maass.   

Abstract

A recent North American study detected Chlamydia pneumoniae in 17 of 19 brains of Alzheimer's patients and supposed a C. pneumoniae infection to be a risk factor for Alzheimer's disease (AD). In this study, we analyzed paraffin-embedded tissue samples of 20 AD patients by nested PCR and immunocytochemistry with a panel of antichlamydial antibodies and could detect neither C. pneumoniae-specific DNA nor chlamydial antigens. From our data, the presence of C. pneumoniae in the brains of Alzheimer's patients is not a common phenomenon; an association remains questionable.

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Year:  2000        PMID： 10655406      PMCID： PMC86233     

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  7 in total

1.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease.

Authors:  S S Mirra; A Heyman; D McKeel; S M Sumi; B J Crain; L M Brownlee; F S Vogel; J P Hughes; G van Belle; L Berg
Journal:  Neurology       Date:  1991-04       Impact factor: 9.910

2.  Multiple sclerosis associated with Chlamydia pneumoniae infection of the CNS.

Authors:  S Sriram; W Mitchell; C Stratton
Journal:  Neurology       Date:  1998-02       Impact factor: 9.910

3.  Argyrophilic inclusions distinct from Alzheimer neurofibrillary changes in one case of dialysis-associated encephalopathy.

Authors:  E Reusche
Journal:  Acta Neuropathol       Date:  1997-12       Impact factor: 17.088

4.  Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.

Authors:  A Hofman; A Ott; M M Breteler; M L Bots; A J Slooter; F van Harskamp; C N van Duijn; C Van Broeckhoven; D E Grobbee
Journal:  Lancet       Date:  1997-01-18       Impact factor: 79.321

5.  Endovascular presence of viable Chlamydia pneumoniae is a common phenomenon in coronary artery disease.

Authors:  M Maass; C Bartels; P M Engel; U Mamat; H H Sievers
Journal:  J Am Coll Cardiol       Date:  1998-03-15       Impact factor: 24.094

6.  Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain.

Authors:  B J Balin; H C Gérard; E J Arking; D M Appelt; P J Branigan; J T Abrams; J A Whittum-Hudson; A P Hudson
Journal:  Med Microbiol Immunol       Date:  1998-06       Impact factor: 3.402

7.  Further characterization of Chlamydia pneumoniae specific monoclonal antibodies.

Authors:  M Puolakkainen; J Parker; C C Kuo; J T Grayston; L A Campbell
Journal:  Microbiol Immunol       Date:  1995       Impact factor: 1.955
  7 in total
  23 in total

1.  Replicate PCR testing and probit analysis for detection and quantitation of Chlamydia pneumoniae in clinical specimens.

Authors:  M Smieja; J B Mahony; C H Goldsmith; S Chong; A Petrich; M Chernesky
Journal:  J Clin Microbiol       Date:  2001-05       Impact factor: 5.948

2.  Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?

Authors:  M R Hammerschlag; Z Ke; F Lu; P Roblin; J Boman; B Kalman
Journal:  J Clin Microbiol       Date:  2000-11       Impact factor: 5.948

3.  PCR search for the herpes simplex virus type 1 genome in brain sections of patients with familial Alzheimer's disease.

Authors:  Isamu Mori; Takashi Yokochi; Naoki Koide; Tsuyoshi Sugiyama; Tomoaki Yoshida; Yoshinobu Kimura; Hironobu Naiki; Rokuro Matsubara; Tohru Takeuchi; Yukihiro Nishiyama
Journal:  J Clin Microbiol       Date:  2004-02       Impact factor: 5.948

Review 4.  Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember?

Authors:  Kensuke Shima; Gregor Kuhlenbäumer; Jan Rupp
Journal:  Med Microbiol Immunol       Date:  2010-05-06       Impact factor: 3.402

5.  Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders.

Authors:  Carlo Contini; Silva Seraceni; Rosario Cultrera; Massimiliano Castellazzi; Enrico Granieri; Enrico Fainardi
Journal:  Interdiscip Perspect Infect Dis       Date:  2010-02-21

6.  Development and evaluation of real-time PCR-based fluorescence assays for detection of Chlamydia pneumoniae.

Authors:  Maria Lucia C Tondella; Deborah F Talkington; Brian P Holloway; Scott F Dowell; Karyn Cowley; Montse Soriano-Gabarro; Mitchell S Elkind; Barry S Fields
Journal:  J Clin Microbiol       Date:  2002-02       Impact factor: 5.948

7.  The association between self-reported tooth loss and cognitive function in the REasons for Geographic And Racial Differences in Stroke study: an assessment of potential pathways.

Authors:  Jonathan C Matthews; Zhiying You; Virginia G Wadley; Mary Cushman; George Howard
Journal:  J Am Dent Assoc       Date:  2011-04       Impact factor: 3.634

Review 8.  Can infections cause Alzheimer's disease?

Authors:  Francis Mawanda; Robert Wallace
Journal:  Epidemiol Rev       Date:  2013-01-24       Impact factor: 6.222

Review 9.  Etiology and pathogenesis of late-onset Alzheimer's disease.

Authors:  Brian J Balin; Alan P Hudson
Journal:  Curr Allergy Asthma Rep       Date:  2014-03       Impact factor: 4.806

10.  Inflammation as a potential mediator for the association between periodontal disease and Alzheimer's disease.

Authors:  Amber Watts; Eileen M Crimmins; Margaret Gatz
Journal:  Neuropsychiatr Dis Treat       Date:  2008-10       Impact factor: 2.570
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