Literature DB >> 11058035

Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro.

J F Sanz-Cervera1, E M Stocking, T Usui, H Osada, R M Williams.   

Abstract

The synthesis of three isoprenylated derivatives of cyclo-L-Trp-L-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly.

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Year:  2000        PMID： 11058035     DOI： 10.1016/s0968-0896(00)00171-1

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Biochemical characterization of a novel indole prenyltransferase from Streptomyces sp. SN-593.

Authors:  Shunji Takahashi; Hiroshi Takagi; Atsushi Toyoda; Masakazu Uramoto; Toshihiko Nogawa; Masashi Ueki; Yoshiyuki Sakaki; Hiroyuki Osada
Journal:  J Bacteriol       Date:  2010-03-26       Impact factor: 3.490

2.  A practical strategy to discover new antitumor compounds by activating silent metabolite production in fungi by diethyl sulphate mutagenesis.

Authors:  Shi-Ming Fang; Chang-Jing Wu; Chang-Wei Li; Cheng-Bin Cui
Journal:  Mar Drugs       Date:  2014-03-27       Impact factor: 5.118

3.  Bioactive Indolyl Diketopiperazines from the Marine Derived Endophytic Aspergillus versicolor DY180635.

Authors:  Yi Ding; Xiaojing Zhu; Liling Hao; Mengyao Zhao; Qiang Hua; Faliang An
Journal:  Mar Drugs       Date:  2020-06-28       Impact factor: 5.118

4.  Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus Aspergillus sp. 16-5c.

Authors:  Geting Ye; Cuiying Huang; Jialin Li; Tao Chen; Jing Tang; Wenbin Liu; Yuhua Long
Journal:  Mar Drugs       Date:  2021-07-20       Impact factor: 5.118
  4 in total

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