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Literature DB >> 1105571

Polypeptide chain initiation in eukaryotes: initiation factor MP in Artemia salina embryos.

Abstract

The activity of IF-MP, a polypeptide chain initiation factor that forms a ternary complex with eukaryotic initiator Met-tRNA and GTP and promotes binding of the initiator to 40S ribosomes, is very low in undeveloped Artemia salina embryos but increases over 20-fold following resumption of development upon hydration of the cysts. The factor is present in both the ribosomal salt wash and high-speed-supernatant. Its specific activity is 50 times higher in the wash but its total activity is only about twice as high in the wash as in the supernatant. As is true of IF-MP from other eukaryotic sources, the A. salina factor is specific for eukaryotic Met-tRNAi and sensitive to SH-reagents, and its activity is GTP dependent.

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Year: 1975 PMID： 1105571 PMCID： PMC433114 DOI： 10.1073/pnas.72.10.3947

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

1. Isolation of protein synthesis initiation factor MP from the high-speed supernatant fraction of wheat germ.

Authors: B V Treadwell; W G Robinson
Journal: Biochem Biophys Res Commun Date: 1975-07-08 Impact factor: 3.575

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Two eukaryotic initiation factors (IF-I and IF-II) of protein synthesis that are required to form an initiation complex with rabbit reticulocyte ribosomes.

Authors: L M Cashion; W M Stanley
Journal: Proc Natl Acad Sci U S A Date: 1974-02 Impact factor: 11.205

4. Met-tRNAfMet binding to 40S ribosomal subunits: a site for the regulation of initiation of protein synthesis by hemin.

Authors: M J Clemens; E C Henshaw; H Rahamimoff; I M London
Journal: Proc Natl Acad Sci U S A Date: 1974-08 Impact factor: 11.205

5. Initiation of eukaryotic protein synthesis: (Met-tRNA f -40S ribosome) initiation complex catalysed by purified initiation factors in the absence of mRNA.

Authors: M H Schreier; T Staehelin
Journal: Nat New Biol Date: 1973-03-14

6. The ternary complex of initiation factor IF-I, MET-tRNA Met f and GTTP. An aurintricarboxylate-sensitive intermediate in the initiation of eukaryotic protein synthesis.

Authors: G L Dettman; W M Stanley
Journal: Biochim Biophys Acta Date: 1973-02-23

7. Isolation of protein synthesis initiation factors from rabbit liver.

Authors: D J Picciano; P M Prichard; W C Merrick; D A Shafritz; H Graf; R G Crystal; W F Anderson
Journal: J Biol Chem Date: 1973-01-10 Impact factor: 5.157

8. Comparative studies on the properties of the eukaryotic protein synthesis initiation factor IF-I from several sources.

Authors: L M Cashion; W M Stanley
Journal: Biochim Biophys Acta Date: 1973-10-26

9. A factor for the binding of aminoacyl transfer RNA to mammalian 40S ribosomal subunits.

Authors: D P Leader; I G Wool; J J Castles
Journal: Proc Natl Acad Sci U S A Date: 1970-10 Impact factor: 11.205

10. A supernatant factor involved in initiation complex formation with eukaryotic ribosomes.

Authors: M Zasloff; S Ochoa
Journal: Proc Natl Acad Sci U S A Date: 1971-12 Impact factor: 11.205

11 in total

1. Regulation of protein synthesis in rabbit reticulocyte lysates: purification and initial characterization of the cyclic 3':5'-AMP independent protein kinase of the heme-regulated translational inhibitor.

Authors: R S Ranu; I M London
Journal: Proc Natl Acad Sci U S A Date: 1976-12 Impact factor: 11.205

2. Polypeptide chain initiation in eukaryotes: mechanism of formation of initiation complex.

Authors: C Nombela; N A Nombela; S Ochoa; B Safer; W F Anderson; W C Merrick
Journal: Proc Natl Acad Sci U S A Date: 1976-02 Impact factor: 11.205

3. A protein binding the methylated 5'-terminal sequence, m7GpppN, of eukaryotic messenger RNA.

Authors: W Filipowicz; Y Furuichi; J M Sierra; S Muthukrishnan; A J Shatkin; S Ochoa
Journal: Proc Natl Acad Sci U S A Date: 1976-05 Impact factor: 11.205

4. Polypeptide chain initiation in eukaryotes: initiation factor requirements for translation of natural messengers.

Authors: W Filipowicz; J M Sierra; C Nombela; S Ochoa; W C Merrick; W F Anderson
Journal: Proc Natl Acad Sci U S A Date: 1976-01 Impact factor: 11.205

5. Role of 3':5'-cyclic-AMP-dependent protein kinase in regulation of protein synthesis in reticulocyte lysates.

Authors: A Datta; C de Haro; J M Sierra; S Ochoa
Journal: Proc Natl Acad Sci U S A Date: 1977-04 Impact factor: 11.205

6. Traversing the RNA world.

Authors: Witold Filipowicz
Journal: J Biol Chem Date: 2017-04-05 Impact factor: 5.157

7. Regulation of protein synthesis in rabbit reticulocyte lysates by the heme-regulated protein kinase: inhibition of interaction of Met-tRNAfMet binding factor with another initiation factor in formation of Met-tRNAfMet.40S ribosomal subunit complexes.

Authors: R S Ranu; I M London; A Das; A Dasgupta; A Majumdar; R Ralston; R Roy; N K Gupta
Journal: Proc Natl Acad Sci U S A Date: 1978-02 Impact factor: 11.205