| Literature DB >> 1104833 |
J P Yardley, T J Foell, C W Beattie, N H Grant.
Abstract
Two varients of LH-RH, less than Glu-D-Phe-Trp-D-Ala-Leu-Arg-Pro-Gly-NH2 (I) and less than Glu-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHCH2CH3 (II), have been synthesized by solid-phase methods. Both peptides strongly inhibit the LH-RH induced secretion of LH in an in vitro assay; however, only I proved effective in preventing ovulation in the 4-day cycling rat.Entities:
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Year: 1975 PMID： 1104833 DOI： 10.1021/jm00246a015
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446