| Literature DB >> 11043777 |
J G Cyster1, K M Ansel, K Reif, E H Ekland, P L Hyman, H L Tang, S A Luther, V N Ngo.
Abstract
Follicular dendritic cells (FDCs), the best defined stromal cell subset within lymphoid follicles, play a critical role in presenting intact antigen to B lymphocytes. The discovery that many follicular stromal cells make B-lymphocyte chemoattractant (BLC), a CXC chemokine that attracts CXCR5+ cells, provides a basis for understanding how motile B cells come into contact with stationary FDCs. Here we review our work on BLC and discuss properties of BLC-expressing follicular stromal cells. We also review the properties of primary follicle and germinal center FDCs and suggest a model of FDC development that incorporates information about BLC expression. Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles.Entities:
Mesh：
Substances：
Year: 2000 PMID： 11043777 DOI： 10.1034/j.1600-065x.2000.00618.x
Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988