Literature DB >> 11038388

Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.

Yvan Verlinden1, Andrea Cuconati2, Eckard Wimmer2, Bart Rombaut1.   

Abstract

In a cell-free system of uninfected HeLa cells, programmed with poliovirus RNA, extraneous radiolabelled 14S subunits assembled with endogenous 14S subunits and interacted with newly synthesized RNA to form virions (160S). This result suggests that 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.

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Year:  2000        PMID： 11038388     DOI： 10.1099/0022-1317-81-11-2751

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


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